Health
Children's gut bacteria linked to autism, stool samples aid diagnosis: researchers
Stool sample Therefore, it is useful for diagnosis Neurodevelopmental disorders According to the researchers, it leads to repetitive behaviors and affects social behavior.
“When autism is suspected, it usually takes three to four years to make a definitive diagnosis, with most children being diagnosed at age six,” the study's lead author, Qi Su from the Chinese University of Hong Kong, told the Guardian.
“our Microbiome Biomarker Panel “It performs well in children under 4 years old and may be useful for early diagnosis,” Su said.
Research over the past decade has shown that gut bacteria play a role in the development of autism in children. Previous studies have shown that children with autism have different gut microbes and a slower development of gut bacterial diversity.
But the researchers said those studies had mainly looked at the bacteria in children's guts.
In this study, the authors investigated other microbes, such as fungi and viruses, and their functions in the gut of children diagnosed with autism.
The researchers analyzed stool samples, along with dietary and medication data, from nearly 1,630 Chinese children aged 1 to 13. Nearly 900 of the children had autism.
The research team analyzed Metagenomic sequence analysisIt is useful for studying genetic material recovered from clinical samples (e.g. stool).
The authors found differences in more than 50 types of bacteria, seven types of fungi, and 18 types of viruses in the gut microbiome of children with autism.
Additionally, 12 metabolic functions were found to be different in these children.
The researchers also Artificial Intelligence-Based Models The aim was to see if the results – the presence of 31 different bugs and features – could be used to predict whether a child has autism.
The researchers found that the model showed “higher diagnostic accuracy” than testing only for a single pathogen, such as bacteria.
“While genetic factors play a major role in autism, the microbiome may act as a contributing factor by regulating immune responses, neurotransmitter production and metabolic pathways,” The Guardian quoted Su as saying.
“This does not necessarily mean causation, but it does suggest that the microbiome may influence the severity and expression of autism spectrum symptoms,” she said.
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