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A systematic review and meta-analysis of 12 studies suggests that meningococcal vaccines are moderately effective against gonorrhea infection, researchers announced yesterday. Infection Journal.
Of the 12 studies, reviewIn a study conducted by a team of Australian researchers, nine studies evaluated the evidence of vaccine effectiveness (VE) of meningococcal B (MenB) outer membrane vesicle (OMV) vaccines against gonorrhea, and one study evaluated the VE of a non-OMV-based vaccine (MenB-FHbp).
Previous studies have shown that the 4-component meningococcal B vaccine (4CMenB) and other OMV-based MenB vaccines Neisseria meningitidis, May provide some cross-protection Neisseria gonorrhoeae, No studies have reviewed the combined evidence on the effect of all meningococcal vaccines on gonococcal infection.
Most of the included studies involved people aged 15 to 30 years in eight countries: Australia, Canada, Cuba, France, Italy, New Zealand, Norway, and the United States. Six of the studies evaluated the VE of the 4CMenB vaccine. Adjusted VE of OMV-based vaccines against gonorrhea ranged from 22% to 46%. Pooled VE estimates of OMV vaccines against gonorrhea infection after a full vaccine series were 33% to 34%. Observed vaccine impacts (VI) ranged from a 30% reduction in gonorrhea incidence in South Australia to a 59% reduction in Quebec, Canada.
The MenB-FHbp vaccine did not provide any protective effect against gonorrhea.
Potential strategies to reduce the incidence of gonorrhea
The study authors note that although variations in VE and VI may be due to differences in vaccination programs, target age groups, and regional epidemiology of gonorrhea, the results are “reassuring regarding cross-protection provided by MenB vaccines.” Gonorrhea With strains resistant to the most commonly used antibiotics on the rise around the world, and with no highly effective gonorrhea-specific vaccine likely to be developed anytime soon, the researchers suggest that a vaccine like 4CMenB is the “most preferred approach” to combat the growing incidence of gonorrhea.
These findings highlight the potential value of incorporating meningococcal vaccination into strategies aimed at controlling gonococcal infection.
“These findings highlight the potential value of incorporating meningococcal vaccination into strategies aimed at controlling gonorrhea, especially in areas with high incidence and limited treatment options due to antibiotic resistance,” the researchers wrote.
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