Health
Study finds 1 in 10 pregnant women with COVID-19 develops long-term COVID-19
a New Research The study, published yesterday, suggests that one in 10 women who get COVID-19 while pregnant will develop long COVID-19. Obstetrics and Gynecology Additionally, there is growing evidence that COVID-19 infection poses unique risks to pregnant women.
Previous studies have found that pregnant women who become infected with the virus are more likely to be hospitalized and die than non-pregnant controls, and COVID-19 during pregnancy also increases the risk of stillbirth and premature birth.
This study was conducted as part of the National Institutes of Health's RECOVER Project, the largest long-COVID study in the United States, and is the first to examine the relationship between prenatal infection and long-COVID, according to the authors.
The majority were infected prenatally during omicron.
The study looked at outcomes among 1,502 U.S. women who had their first COVID infection while pregnant between December 2021 and September 2023, assessing self-reported long COVID symptoms at least six months after infection.
More than half of the participants, 61%, were first infected after December 2021, when the Omicron variant was dominant, and 51.4% had been fully vaccinated before infection.
The prevalence of long COVID is 9.3% (95% CI [CI](median: 7.9%-10.9%), with increased mortality 10 months after initial infection.
According to the study authors, the most commonly reported long COVID symptoms were post-exertional malaise (77.7%), fatigue (76.3%), and gastrointestinal symptoms (61.2%).
Obesity and mental health increase risk of long COVID-19
Several pre-pregnancy factors were associated with an increased likelihood of long-term COVID-19 disease, most notably obesity (adjusted odds ratio[ADOR]0.054). [aOR]1.65; 95% CI, 1.12-2.43), history of anxiety or depression (aOR, 2.64; 95% CI, 1.79-3.88), and treatment with oxygen during acute SARS-CoV-2 infection (aOR, 1.86; 95% CI, 1.00-3.44).
“We were surprised that the prevalence was so high,” said Tori Metz, MD, vice chair of research in obstetrics and gynecology at the University of Utah Health, who co-led the nationwide study. press release “This continues to affect younger, healthier people,” the University of Utah researchers said.
It continues to affect younger, healthier people too.
Metz said many otherwise healthy women experience many symptoms similar to long COVID during pregnancy and the early postpartum period, making it difficult to diagnose.
“We need to keep this in mind when we're seeing patients – it's something we definitely don't want to miss – and we want to refer patients to the right specialists who can treat long COVID-19,” she said.
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