Health
Too much fat in these areas could increase risk of Alzheimer's and Parkinson's disease, study suggests
Top Line
High levels of abdominal and arm fat may increase the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's, but greater muscle strength may lower this risk, suggests a new study exploring the link between body composition and brain degeneration.
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Key Facts
The study involved 412,961 participants aged between 40 and 70 years old who were followed for an average of about nine years. During this time, 8,224 people developed neurodegenerative diseases, primarily Parkinson's disease, Alzheimer's disease, or other forms of dementia.
In a study published Wednesday in Neurology, the medical journal of the American Academy of Neurology, researchers found that participants with excess arm fat had an 18% higher risk of developing these disorders compared with those with less arm fat.
Participants with higher levels of abdominal fat were also 13% more likely to develop these neurodegenerative diseases, and this risk was slightly higher in men than women.
But there was one factor that consistently lowered participants' risk: greater muscle strength reduced their risk by more than 25%.
previous the study Although higher lean muscle mass (the difference between body weight and body fat) has been found to be associated with a reduced risk of neurodegenerative disease, Neurology Study researchers found inconsistent results regarding this factor, suggesting that muscle quality, rather than muscle quantity, may play a more important role in reducing risk.
Important Quotes
“Targeted interventions that promote healthy muscle development while reducing fat in the trunk and arms may be more effective in preventing these diseases than general weight management,” Dr. Huang Song, a professor at Sichuan University in China and an author of the study, said in a statement.
Why does excess fat increase the risk of neurodegenerative diseases?
One reason high levels of abdominal fat increase your risk is due to a type of fat called visceral fat, which is found only around the abdominal organs.Hidden fat” Located in the stomach and invisible to the naked eye, visceral fat is thought to accumulate in fat cells. A 2023 study found that middle-aged people with excess visceral fat had elevated levels of tau and amyloid proteins in the brain, both of which are indicators of Alzheimer's disease. study The study was published in the journal Aging & Disease. found Obesity significantly increases the risk of developing neurodegenerative diseases: Although the brain naturally shrinks with age, obesity accelerates this process, aging the brain by about 10 extra years and increasing the risk of Alzheimer's disease. according to According to the Alzheimer's Association, metabolic changes associated with excess fat can damage the central nervous system and lead to neuronal cell death, a known cause of neurodegenerative diseases. study It was suggested.
tangent
Researchers in the neurology study also looked at how cardiovascular disease, such as heart disease and stroke, may affect the development of degenerative brain diseases. About 35% and 22% of participants with excess abdominal and arm fat, respectively, developed some form of cardiovascular disease after the study began, before they developed neurodegenerative diseases. Cardiovascular disease is associated with: Previously linked It's a known risk factor for neurodegenerative disease, and researchers believe that treating cardiovascular disease early could help reduce neurodegeneration in people with excess arm and abdominal fat.
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Big numbers
30 million people. That's the number of people worldwide who suffer from degenerative brain diseases. according to To the Cleveland Clinic.
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Sources 2/ https://www.forbes.com/sites/ariannajohnson/2024/07/24/excess-arm-and-stomach-fat-boosts-alzheimers-and-parkinsons-risk-while-muscle-strength-decreases-it-study-suggests/ The mention sources can contact us to remove/changing this article |
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