Health
Less invasive approach promises for drug testing for rare fetal blood disorder
Data from a new investigational drug that could change the standard of care for a rare blood disorder suggests it may delay or prevent anemia and the need for intrauterine blood transfusions in babies at high risk for the condition, known as hemolytic disease of the fetus and newborn (HDFN). New England Journal of Medicine.
HDFN is a serious condition in which the blood types of the mother and fetus are mismatched, potentially causing life-threatening anemia in the fetus. The current standard of care for HDFN requires an average of four ultrasound-guided intrauterine blood transfusions during pregnancy. Transfusion-related complications include fetal death, premature rupture of membranes, and premature birth.
“If further studies support the use of nipocalimab to treat HDFN, treating the fetus in these pregnancies may be safer and easier for pregnant women,” said lead researcher Kenneth Moise, Jr., MD, an expert in maternal-fetal medicine. Moise is a professor in the Department of Women's Health at Dell Medical School at The University of Texas at Austin and co-director of the Center for Comprehensive Fetal Care, a clinical practice at Dell Medical School, a clinical affiliate of Dell Children's Medical Center and University of Texas Health Austin.
The study, called the UNITY study, followed 13 pregnant women who had experienced fetal loss or required early intrauterine transfusion during a previous pregnancy due to HDFN. DNA testing revealed that their current fetuses were also at high risk for HDFN. Participants received intravenous nipocalimab between weeks 14 and 35 of pregnancy.
More than half of the study participants (54%) delivered live babies after 32 weeks without needing a blood transfusion, some even remaining transfusion-free after birth. None of the babies developed a dangerous HDFN condition called hydrops fetalis, a condition in which too much fluid builds up inside the fetus, reducing the baby's chances of survival.
In HDFN, nipocalimab works by blocking the transfer of antibodies across the placenta, preventing them from attacking the fetus's red blood cells and reducing the amount of antibodies in the mother's bloodstream.
“Nipocalimab is the only agent in development with the potential to treat a range of alloimmune diseases affecting the fetus, including fetal/neonatal alloimmune thrombocytopenia and immune-mediated congenital heart block,” Moïse said. Nipocalimab also has the potential to treat a wide range of autoantibody diseases, including rheumatoid arthritis and myasthenia gravis, he said.
Later in 2023, Johnson & Johnson, sponsor of the UNITY Phase 2 trial, will launch a pivotal Phase 3 trial of nipocalimab in HDFN, called AZALEA. Earlier this year, researchers began enrolling pregnant women who are at risk for severe HDFN and have experienced the condition in a previous pregnancy to further evaluate the efficacy and safety of nipocalimab. The AZALEA trial is a randomized controlled trial being conducted in maternal-fetal centers around the world. Moise is the principal investigator of the Phase 3 trial in Central Texas.
|
Sources 2/ https://www.sciencedaily.com/releases/2024/08/240807225457.htm The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
