Health
Unique strain of probiotic bacteria shows potential to fight inflammatory diseases
A significant unmet need exists to strengthen the intestinal barrier and keep it healthy, thus treating leaky gut. Researchers have found that a unique strain of probiotic bacteria may: Bifidobacteria BB1 enhances the intestinal barrier function and prevents the infiltration of intestinal bacteria and various harmful substances. American Journal of PathologyThe study, published by Elsevier, could help facilitate the development of new, targeted, natural probiotic therapies for patients with inflammatory bowel disease (IBD) and other inflammatory diseases. Fatty liver disease or diseases associated with a leaky or impaired intestinal barrier, such as alcoholic liver disease.
“The study is a first-of-its-kind opportunity for patients with pulmonary circulation problems,” explains lead researcher Thomas Y. Marr, MD, of Pennsylvania State University Hershey Medical Center. “The development of non-toxic, patient-friendly natural products such as probiotics is crucial for the treatment of IBD and other inflammatory diseases associated with leaky gut. Our study suggests that BB1 is such a precision probiotic strain. BB1 has unique biological activity to maximally strengthen the intestinal barrier and prevent inflammatory activation.”
In patients with active IBD, levels of proinflammatory cytokines, including tumor necrosis factor (TNF), are increased.be and IL1β. TNF-be TNF-α levels are significantly elevated in the intestinal tissue, serum, and stool of IBD patients, and elevated levels are associated with increased intestinal tight junction permeability.be plays a central role in promoting intestinal inflammation in IBD patients and is anti-TNF-be The antibody is highly effective in treating active disease, and previous research from laboratories at the Pennsylvania State University College of Medicine has shown that BB1 significantly enhances intestinal epithelial barrier function and prevents the development of dextran sulfate sodium-induced enteritis.
Dr Ma added: “Our results suggest that BB1 inhibits TNF-be Increased intestinal tight junction permeability and inhibition of NF-κB p50/p65 activation via the Toll-like receptor (TLR)-2 signaling pathway. MLCK Gene. We also found that a protein called PPAR-γ is a key enterocyte mediator that controls intestinal barrier protection. Treating patients with active ulcerative colitis with the PPAR-γ agonist rosiglitazone significantly reduced their Ulcerative Colitis Disease Activity Index scores and improved their quality of life.
Dr Ma concludes: “These studies elucidate a novel intracellular mechanism for the unique probiotic bacterial strain BB1, demonstrating its potential to promote health by maintaining a healthy intestinal barrier and preventing leaky gut and intestinal barrier breakdown, as well as treat inflammatory diseases, including inflammatory bowel disease.”
IBD, including Crohn's disease and ulcerative colitis, is an inflammatory disease of the gastrointestinal tract. Defects in the intestinal epithelial tight junction barrier are an important pathogenic factor contributing to the development of IBD. IBD patients have defective intestinal tight junction barriers and are characterized by increased intestinal permeability and increased luminal antigen penetration. Intestinal epithelial cells cover the entire intestinal mucosal surface and act as a physical and functional barrier against the intestinal penetration of harmful luminal substances such as bacteria. antigentoxins, digestive enzymes, food by-products, etc.
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Journal References:
Abdulkadir, R. Others. (2024) Bifidobacterium bifidum strain BB1 inhibits TNF-α-induced increase in intestinal epithelial tight junction permeability via TLR-2/TLR-6 receptor complex-dependent PPAR-γ stimulation and NF-κB p65 suppression. American Journal of Pathology. doi.org/10.1016/j.ajpath.2024.05.012.
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