We may one day be able to slow, stop, or even eliminate Alzheimer's disease.

Alzheimer's disease is, understandably, one of the most feared diseases of old age. It robs people of their memories, places a tremendous strain on caregivers, and imposes a huge economic burden on both individuals and society. Tens of millions of people have already been diagnosed with Alzheimer's, and if predictions are correct, that number will more than double by 2050.

Until recently, there seemed to be no hope of averting this catastrophe, but rapid medical advances have made it possible Alzheimer's Disease It is treatable and can eventually be eradicated ( A new kind of vaccine could eradicate Alzheimer's disease).

First A new kind of drug It's already making waves, but not necessarily for the right reasons. Last week, the UK's Medicines and Healthcare products Regulatory Agency approved the drug, called lecanemab. But NICE, the body that advises on whether new treatments are cost-effective, has made a provisional decision that the drug will not be funded by taxpayers in England. No decision has yet been made in the rest of the UK.

This is obviously a tough pill to swallow for Alzheimer's patients and their families. But in the grand scheme of things, this is good news. Lecanemab is not a particularly effective drug. Its effects are modest, it has serious side effects, and it is expensive. But it does show that the causes of Alzheimer's are now understood and treatable. This is further reinforced by the fact that the drug is also approved in the United States and Japan, but the European Medicines Agency has refused to approve it.

The road to the next wave of drugs targeting the causes of Alzheimer's disease is therefore almost paved, and could be ready around 2030. vaccine Unlike conferring immunity against an infection in the traditional sense, they essentially work in the same way, by prompting an immune response — in this case, a response to the misfolded proteins that cause the symptoms of Alzheimer's. The first vaccines will be therapeutic vaccines that slow or stop the progression of the disease, but the next generation will be preventative vaccines designed to stop the disease from progressing. Eventually, only memories of Alzheimer's itself will fade.

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