Health
Weight loss drugs linked to fewer COVID-19 deaths – Harvard Gazette
A clinical trial led by Harvard's Brigham and Women's Hospital and funded by Novo Nordisk, maker of Wegovy (the brand name for semaglutide), found that an injection of the weight-loss drug Wegovy reduced the risk of death from COVID-19 by about a third and also significantly reduced the risk of death from cardiovascular disease and other causes.
From October 2018 to March 2023, researchers looked at the effect of weekly Wegobee injections versus a placebo on mortality in more than 17,000 subjects with heart disease and overweight or obesity. The study showed that patients who took Wegobee were about 15% less likely to die from cardiovascular disease and 23% less likely to die from other causes than those who took a placebo. Overall mortality in the Wegobee group was 19% lower than the placebo.
“This trial began before the COVID-19 outbreak and did not anticipate a global respiratory disease pandemic,” said corresponding author Benjamin M. Sirica, director of quality initiatives in BWH's cardiovascular division and professor of medicine at Harvard Medical School.
“It is rare for cardiometabolic drugs to improve non-cardiovascular outcomes,” Sirica added. “The fact that semaglutide reduced non-cardiovascular deaths, particularly COVID-19-related deaths, was surprising and opens new avenues for exploring how this class of drugs can benefit patients.”
In this study, people who took Wegovy were just as likely to become infected with COVID-19, but experienced less severe illness and death related to COVID-19. The researchers are unclear whether the effects of Wegovy are due to weight loss or other effects, but they suggest that excess weight may be the biggest factor in shortening lifespan. Although this is a large, multinational study, it is based on only one observation, so the results need to be replicated. Further research should explore potential mechanisms of action, and other studies of this class of drug should provide additional data.
result It was published in the Journal of the American College of Cardiology.
Disclosure: Benjamin Sirica reports institutional research grants from Better Therapeutics, Merck, Novo Nordisk, and Pfizer to Brigham and Women's Hospital, consulting fees from Allergan, Amgen, Boehringer Ingelheim, Better Therapeutics, Elsevier Practice Update Cardiology, Esperion, Hanmi, Lexicon, and Novo Nordisk, and Health Equity. [at] Scale and proximity.
Novo Nordisk funded the study and was responsible for the study design in collaboration with the Scientific Steering Committee, contributed to the collection, analysis and interpretation of data, and participated in the preparation and review of the manuscript in collaboration with the authors.
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