Health
Unfold AI outperforms traditional methods in predicting prostate cancer risk
A recently published study in BJUI Compass confirms the groundbreaking potential of Unfold AI™, an FDA-approved artificial intelligence (AI) algorithm developed by Avenda Health, a leader in personalized treatment for prostate cancer. In collaboration with UCLA, the study used Unfold AI's technology to map 3D cancer probability and estimate extracapsular extension (ECE) risk, comparing it to traditional methods, including MRI, PSMA PET/CT images, and nomograms. Results revealed that Unfold AI accurately predicted ECE risk, outperforming traditional methods and helping surgeons more accurately predict extraprostatic disease extension.
ECE is the spread of cancer beyond the prostate into the surrounding soft tissues, increasing the risk of positive surgical margins and increasing the likelihood of recurrence and metastasis. The presence of ECE is crucial in determining treatment options and assessing the risk to quality of life for patients with prostate cancer, and accurate identification of ECE is essential to reduce cancer recurrence.
The study retrospectively analyzed data from 147 patients who underwent MRI-targeted therapy. biopsy Following radical prostatectomy, Unfold AI was found to have a significantly higher predictive value for patient-level ECE prediction than all other standard of care methods evaluated. Unfold AI also demonstrated a significant reduction in false negatives by 40%-60% compared to MRI.
By more accurately assessing extracapsular spread, our AI tool empowers physicians to make informed decisions, ultimately improving patient outcomes and setting a new benchmark in diagnostic accuracy. This advancement not only advances the accuracy of cancer detection, but also marks a milestone in our commitment to personalized medicine and better patient care.”
Shyam Natarajan, CEO of Avenda
This study builds on previous research published in The Journal of Urology, which demonstrated Unfold AI's ability to improve physician accuracy in identifying the extent of prostate cancer by 84%. In addition to these milestones, Unfold AI has been included as a Category III code in the American Medical Association's 2024 Current Procedural Terminology code set. This new classification makes Unfold AI billable for insurance, improving access to personalized prostate cancer treatment.
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