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Today's Research A study of 1,296 Italian pediatric COVID-19 patients followed multiple times over two years shows a decrease in the rate of long COVID over time. Clinical Medicine This is one of the longest-term studies conducted on children with long COVID-19.

The findings are based on observations at a single clinic in Rome from January 2020 to February 2024. At follow-up visits 3, 6, 12, 18 and 24 months after confirmed COVID-19 infection, 23.2%, 13.2%, 7.9%, 6.1% and 7.1% were diagnosed with long COVID, respectively.

Early in COVID infection, 8.6% (114) were asymptomatic, 88.6% (1,169) had mild symptoms, 2.2% (29) had moderate symptoms, and 0.2% (2) had severe symptoms. Most children were diagnosed with COVID-19 when the Omicron variant was circulating (939, 71.2%). More than three-quarters (79.6%) of children had not been vaccinated before infection, while 6.2%, 12.6%, and 5.2% of children had received one, two, and three doses of a COVID-19 vaccine, respectively.

Ageing is associated with longer COVID-19

Two factors were associated with an increased risk of COVID long diagnosis over 18 months: age 12 years or older (odds ratio [OR]9.37; 95% CI [CI]1.58-8.64) and being infected with the original strain (OR, 3.52; 95% CI, 1.32-8.64) or alpha strain (OR, 4.09; 95% CI, 2.01-8.30) of the virus.

Older age, primary infection and alpha infection were associated with long COVID at 3 months, as were female sex and comorbidities.

A diagnosis of Long-COVID was considered if symptoms persisted or new symptoms developed 3 months after the initial SARS-CoV-2 infection.

COVID-19 vaccines were associated with a reduced risk of developing long COVID, especially in adolescents.

“COVID-19 vaccines are associated with a lower risk of developing long COVID, especially in adolescents, and reinfection was a minimal burden for most patients, although one case of long COVID following reinfection was identified,” the authors wrote.

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