Dye in Doritos makes mice's skin transparent in a 'magic trick', new study finds

Food colorings commonly used in popular snack foods Doritos A new study conducted by scientists at Stanford University has found that absorbing molecules can make mouse skin transparent. In a paper published in Science on September 5th titled “Absorbing Molecules Achieve Optical Transparency in Living Animals,” the researchers detailed how they were able to see through the skin of living mice.

Dye in Doritos makes mice's skin transparent

The experiment was led by Dr. Zihao Ou, an assistant professor of physics at Shanghai University. Texas In the Dallas experiment, researchers aimed to find a better way to view tissues and organs inside the body. They applied a mixture of water and tartrazine, a common food coloring known as FD&C Yellow 5, to the skull and abdominal skin of live mice, making them transparent.

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“For those who understand the fundamental physics behind this, it makes sense, but for those who aren't, it looks like magic,” Ou said in a description of the research posted on the university's website. “It takes a few minutes for the transparency to occur, similar to how a facial cream or mask works. The time needed depends on how quickly the molecules penetrate the skin.”

“We combined a yellow dye, a molecule that absorbs most light, especially blue and ultraviolet light, with skin, which is a scattering medium. These two alone block most light, but by combining them, we were able to achieve transparent mouse skin,” Ou explained. Once the skull skin was transparent, the researchers were able to directly observe blood vessels on the surface of the mouse brain.

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Meanwhile, in the abdomen, they were able to observe muscle contractions in the internal organs and digestive tract. The announcement noted that the scientists have not yet tested the process in humans. Ou explained that human skin is about 10 times thicker than that of mice, so it is unclear what dosage or delivery method of the dye would be needed to penetrate the entire skin.

Regarding the application of the results of this research to the medical field, Oh said, “Since most of our research group are academics, one of the first thoughts we had when we saw the results was how this could improve biomedical research. Optical instruments such as microscopes have not been directly used to study living humans or animals because light cannot pass through biological tissue. However, by being able to make tissue transparent, we can now see more detailed dynamics. This will completely revolutionize existing optical research in biology.”

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