Karill said the researchers chose the drug because the study showed that people with more severe COVID-19 disease had lower levels of protein in the blood and lungs.
Health
UNMC Launches Third Phase of Federal Government COVID-19 Drug Trial | Health and Exercise
“The hypothesis we have is that this very tough battle between the virus and our immune system causes us to deplete this very important molecule with direct antiviral properties. That’s what he said.
By adding lemdecivir, which supplements the protein and targets the virus’s ability to replicate, they hope to create a synergistic effect, Karill said.
Since interferon has been used as a treatment for many years, researchers are fully aware of how it works and its safety.
Researchers plan to enroll approximately 1,000 patients with COVID-19-related pneumonia in nearly 100 hospitals worldwide. All patients take lemdecivir, but half take the new drug and half take the placebo. Neither researchers nor participants know who has which combination. According to NIH, the drug is marketed under the brand name Rebif by EMD Serono, a North American division of the German pharmaceutical company Merck.
The researchers will evaluate whether the combination shortens patient recovery time compared to lemdecivir alone.
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