Health
Autoimmune diseases and premature ovarian dysfunction
Top line:
woman with premature baby ovarian dysfunction (POI) The prevalence of severe autoimmune diseases is 2.6 times higher before diagnosis, and the risk of these diseases increases by 2-3 times after diagnosis.
Methodology:
- Researchers conducted a population-based registry study that included 3972 women diagnosed with spontaneous POI between 1988 and 2017.
- A total of 15,708 female population controls matched by age and municipality of residence were included for comparison.
- Autoimmune disease diagnosis was assessed using hospital discharge registries from childhood until the end of 2017.
- Women with a history of cancer or bilateral cancer oophorectomy were excluded from the study.
remove:
- Women with POI had a 2.6 times higher prevalence of severe autoimmune disease before diagnosis compared to controls (odds ratio) [OR]2.6; 95% CI, 2.2-3.1).
- Prevalence of certain autoimmune diseases such as polyglandular autoimmune diseases (OR, 25.8; 95% CI, 9.0-74.1) Addison's disease (OR, 22.9; 95% CI, 7.9-66.1) was significantly higher in women with POI.
- The standardized incidence of being diagnosed with a severe autoimmune disease after POI diagnosis was 2.8 (95% CI, 2.3 to 3.4) during the first 3 years and 1.3 (95% CI, 1.1 to 1.6) after 12 years. decreased to
- No significant differences were found in the prevalence of type 1 diabetes and ankylosing spondylitis between POI women and the reference cohort.
actual:
“The findings strengthen the hypothesis that autoimmune mechanisms play an important role in the development of POI.Future studies should focus on the immunological mechanisms of POI from the perspective of prevention and treatment. “Yes,” the study authors wrote.
sauce:
The study was led by Susanna M. Sabkoski from Oulu University Hospital in Oulu, Finland. Published online was human reproduction.
Limitations:
This study included only autoimmune diseases diagnosed in a professional medical setting, which may underestimate the overall prevalence of autoimmune diseases in women with POI. Furthermore, this study did not take into account confounding factors such as BMI and smoking, which are associated with the risk of autoimmune diseases and POI.
Disclosure:
Susanna M. Subkoski has received grants from the Finnish Menopause Society, the Finnish Medical Foundation, and the Juho Vainio Foundation. Additional disclosures can be found in the original article.
This article was created using several editing tools, including AI as part of the process. A human editor reviewed this content before publication.
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Sources 2/ https://www.medscape.com/viewarticle/severe-autoimmune-diseases-linked-premature-ovarian-2024a1000hye The mention sources can contact us to remove/changing this article |
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