Genomics England is part of a multi-million pound UK-wide platform…

Genomics England is part of a national team of universities, hospitals and industry led by the Francis Crick Institute and the Royal Marsden NHS Foundation Trust to develop a new platform for understanding the responses and side effects of immunotherapy in cancer. has been launched.

Funded by £9m from the Medical Research Council and Office for Life Sciences, and £12.9m matched by industry partners, the program will see thousands of patients treated with immunotherapy from across the UK. join.

Drugs that help the immune system fight cancer, collectively known as immunotherapy, are front-line treatments for some types of cancer, such as melanoma. Long-term studies have shown that advanced disease can be completely eradicated in some patients.

However, the majority of cancer patients do not benefit, and many end up having recurrence or experiencing serious side effects. Even in the most effective melanomas, only 50% respond.

New programs across the UK include:MANIFEST (Multidimensional Analysis of Immunotherapy Characteristics Demonstrating Success and Toxicity)was set out to assess the many barriers to immunotherapy success.

These include the lack of testable and usable biomarkers that suggest to doctors whether a person would benefit from a particular drug. Identifying these biomarkers may not only help select patients who are most likely to benefit, but also pave the way for new treatments such as vaccines and cell therapies.

MANIFEST aims to develop tests that can verify which biomarkers are present in patients before starting immunotherapy and monitor them during treatment.

Initial testing includes 3,000 patients with breast, bladder, kidney and skin cancers and 3,000 patients starting treatment across the UK, with additional cancer types to be added as the program expands It is scheduled to be done.

Data will be collected from these patients over a four-year period using procedures such as blood tests, stool samples, and tissue biopsies.

The research team plans to analyze various aspects of cancerous tumors, including their genetic makeup, their relationship with immune cells, and what chemical signals cancerous tumors emit. We also plan to generate a profile of immune cells in each patient's bloodstream and analyze their gut microbiome.

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