Health
Induction chemotherapy increases survival rates for cervical cancer
Top line:
Induction chemotherapy followed by chemoradiotherapy improves 5-year overall survival in advanced patients cervical cancer From 72% to 80%. This treatment also improves the 5-year progression-free survival rate from 64% to 72%.
Methodology:
- Researchers conducted the multicenter, randomized, phase 3 INTERLACE trial to assess whether short-term induction chemotherapy before chemoradiotherapy was more effective than chemoradiotherapy alone.
- A total of 500 adults with locally advanced cervical cancer were randomly assigned to receive standard chemoradiotherapy alone or induction chemotherapy followed by chemoradiotherapy.
- Induction chemotherapy consists of weekly i.v. carboplatin and Paclitaxel 6 weeks, then standard Cisplatin-Based chemoradiotherapy.
- The primary endpoints were progression-free survival and overall survival, with a median follow-up of 67 months.
- The trial involved patients from 32 medical centers in Brazil, India, Italy, Mexico, and the United Kingdom and adhered to the principles of the Declaration of Helsinki, good clinical practice guidelines, and applicable local regulatory requirements.
remove:
- Induction chemotherapy followed by chemoradiotherapy significantly improved 5-year progression-free survival from 64% to 72% (hazard ratio). [HR]0.65; 95% CI, 0.46-0.91; P = .013).
- Induction chemotherapy followed by chemoradiotherapy increased 5-year overall survival from 72% to 80% (HR, 0.60; 95% CI, 0.40-0.91; 95% CI, 0.40-0.91; P = .015).
- Grade 3 or higher adverse events were more common in the induction chemotherapy group (occurring in 59% of these patients) than in the chemoradiotherapy alone group (occurring in 48% of these patients).
- Distant-only recurrence was lower in the induction chemotherapy group (occurred in 7%) than in the chemoradiotherapy alone group (occurred in 12%). P = .015).
actual:
“Induction chemotherapy performed according to the INTERLACE protocol should be incorporated into clinical guidelines as an option to improve outcomes for patients with locally advanced cervical cancer. could be incorporated into the design of future clinical trials,” the study authors wrote.
sauce:
The study was led by Dr Mary McCormack from University College London Hospitals NHS Foundation Trust in London, UK. it was Published online on October 14th lancet.
Limitations:
Limitations of this study included exclusion of patients with FIGO 2008 stage IIIA disease and para-aortic lymph nodes, which may have limited the generalizability of the findings. Additionally, the long recruitment period of 10 years may have influenced the results. This study also presented challenges in adhering to stringent radiotherapy quality assurance requirements.
Disclosure:
McCormack, MSD, Eisai, GSK, Roche, and Medscape Medical News. Additional disclosures can be found in the original article.
This article was created using several editing tools, including AI as part of the process. A human editor reviewed this content before publication.
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Sources 2/ https://www.medscape.com/viewarticle/induction-chemotherapy-followed-chemoradiotherapy-improves-2024a1000iz2 The mention sources can contact us to remove/changing this article |
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