Health
Researchers identify three new genetic variants associated with breast cancer in men
Scientists have identified three new variants of DNA that increase the risk of breast cancer in men, totaling five.
Variants are already associated with breast cancer in women, but researchers say they have found that these genetic changes have a greater impact on disease risk in men than in women.
Scientists have found that a study published in the Journal of the National Cancer Institute suggests that breast cancer has a similar genetic basis in both men and women, leading to a greater risk of male cancer. It states that it may lead to tests and the development of new preventive drugs for them at high risk of disease.
Dr. Nick O’Hour, lead author of research at the Cancer Institute in London, said: “There has been much debate about whether breast cancer in women and men differ from each other.
“Our study, for the first time, showed that the genetic factors that affect susceptibility to breast cancer in men and the most common type of breast cancer in women are much more similar than they are different.
“Our findings suggest that the underlying biology that affects the development and growth of breast cancer is probably similar in men and women.
“This means that advances in disease prevention and treatment can benefit all patients, regardless of gender.”
The exact cause of breast cancer in men is not known, but it carries the risk of getting the disease, such as inheriting a defective version of a gene called BRCA1 or BRCA2 or a condition that can increase the levels of estrogen in the body. There is something to enhance.
Breast cancer is rare in men. About 350 men are diagnosed each year in the UK, compared to about 55,000 women.
The study was partially funded by Breast Cancer Now and involved scientists from the Cancer Institute and Queen’s University Belfast.
The team analyzed data from 1,380 men with breast cancer, which is considered to be the largest genetic study of breast cancer in men to date.
They compared the genomic or genetic material of these men to 3,620 disease-free men.
Scientists have found that three genetic changes, called rs9371545, rs554219, and rs78540526, are associated with increased breast cancer risk in men by 47%, 45%, and 61%, respectively.
In addition, the study showed that men at highest genetic risk were almost four times more likely to develop breast cancer than men at lowest risk.
The researchers also found a “strong correlation” between genetic risk factors for breast cancer in men and women, with 20% of changes affecting women’s risk of breast cancer having similar effects on breast cancer risk in men. Said that it has caused.
Dr. Simon Vincent, head of research, services and influence at Brest Cancer Now, said: “This study shows a greater similarity in genetic causes of male and female disease than previously thought, and is a huge step forward.
“Our knowledge of male breast cancer is limited. Because male breast cancer is rare, it is difficult to collect enough tissue or blood samples to study and understand the disease.
“We look forward to further exploring the common genetic causes of breast cancer in men, which could lead to the development of higher-risk treatments and interventions in the future.”
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