Health
Air pollution and head and neck cancer
Top line:
Exposure to particulate matter (PM) less than 2.5 μm2.5) is associated with increased incidence of head and neck cancer (HNC), with the strongest association observed at a 5-year lag period. This study highlights the need for further subgroup analyzes to understand the relationship between exposure and cancer development.
Methodology:
- The researchers conducted an epidemiological cohort analysis using data from the 2002-2012 national cancer database Surveillance, Epidemiology, and End Results.
- In this study, we investigated the relationship with county average PM in the United States.2.5 HNC incidence and levels using a linear mixed model, focusing on the overall and site-specific incidence of HNC.
- The analysis includes more than 600 counties and 11 states in total, and data is linked to county-level air pollution, alcohol, and tobacco data.
- Age-adjusted incidence rates for HNC were calculated for each county, and a lag model was utilized to account for the time from exposure to disease onset.
- The primary outcome was all HNC incidence, with secondary outcomes including specific cancer subtypes such as oral cavity, oropharyngeal, laryngeal, hypopharyngeal, sinus, and middle ear cancer. was included.
remove:
- afternoon2.5 Exposure is significantly associated with increased incidence of HNC, with the strongest association observed at the 5-year lag period (β, 0.24; P < .001).
- A significant association was also observed without delay (β, 0.16; P = .02), maximum lag period of 20 years (β, 0.15; P < .001).
- According to research, PM2.5 Even after adjusting for covariates, exposure is associated with increased incidence of certain HNC subtypes, such as oral cavity and laryngeal cancers.
- After adjusting for covariates, no significant associations were found for sinus, hypopharyngeal, nasopharyngeal, and oropharyngeal cancer.
actual:
“This study adds to the growing body of literature supporting improved air quality standards to reduce the impact of air pollution on the development of cancer,” the study authors wrote.
sauce:
The study was led by John Kramer of Wayne State University in Detroit and Stella E. Lee of Brigham and Women's Hospital in Boston. Published online was scientific report.
Limitations:
This study was limited by its ecological design, which made it difficult to control for all confounding variables. “Prior to 1996, there were also limited smoking and alcohol data available at the county level, and other important covariate data on occupational exposures and racial/ethnic disparities were not available during the study period. “There was no such thing,” the authors write. Furthermore, the effects of virus-induced carcinogenesis, particularly human papillomavirus in the oropharynx and Epstein-Barr virus in the nasopharynx, were not considered due to limited data available.
Disclosure:
The authors report no relevant conflicts of interest.
This article was created using several editing tools, including AI as part of the process. A human editor reviewed this content before publication.
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Sources 2/ https://www.medscape.com/viewarticle/air-pollution-exposure-linked-increased-head-and-neck-cancer-2024a1000knp The mention sources can contact us to remove/changing this article |
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