Health
Will daily low-dose aspirin in the elderly accelerate cancer?
Wednesday, August 12, 2020 (HealthDay News)-Taking low-dose aspirin daily may accelerate cancer progression in older people, according to a new clinical trial.
Daily aspirin doubles the risk of dying of stage 3 cancer in people aged 70 and older, with nearly 3 mortality risks associated with stage 4 cancer, according to data from more than 19,000 elderly people in the United States and Australia. Increased by a factor of 1.
Older patients who take aspirin daily also have an approximately 20% increased risk of cancer spreading to other parts of the body before or after diagnosis, the researchers found.
Convincing evidence from previous clinical trials has shown that aspirin taken daily by middle-aged people may reduce the risk of cancer, especially colon cancer, the researchers said in the background. I will.
However, in the new study, researchers found that older people who developed late-stage cancer “prone to worse when taking aspirin,” the researchers found. In Boston. “It suggests a potential difference in the effects of aspirin on older people compared to younger adults.”
Based on these new findings, older people should seriously discuss with their doctors before starting a low-dose daily course of aspirin, says Franksinini, a gastroenterologist at the Mayo Clinic in Rochester, Minnesota. Dr. Klope said.
“This study certainly raises concerns about the use of low-dose aspirin in people over the age of 70. It raises concerns about the potential for advanced cancer in these older patients,” Sinicrope said. It was “I think they need it to talk to their doctor and see what the risks/benefits are.”
In clinical trials, researchers randomly assigned people over 70 years of age to 100 milligrams of aspirin or placebo per day for an average of nearly 5 years. The majority of study participants did not take aspirin daily by age 70.
Of more than 19,000 participants, 981 people taking aspirin and 952 taking placebo developed cancer during follow-up.
Analysis showed that low doses of aspirin did not increase the risk of developing cancer, but appeared to be associated with more aggressive cancers.
“Scientists assume that aspirin works the same in all individuals, but the effects may be different in older people,” Chan said.
He said there are two reasons why this difference exists between middle-aged and elderly aspirin users.
For one, the anti-cancer effects of aspirin may only work if people start taking aspirin at a young age. “It can be too late if you start taking it as you get older,” Chan explained.
Another theory is that cancer in older people is somehow different from cancer in younger people.
“The mechanisms of these cancers may be different and may be less sensitive to aspirin than cancers that live in young adults,” Chan suggested.
These results were “a big surprise” for Peter Campbell, the science director of epidemiology research at the American Cancer Society.
He said a larger study, including more clinical trial data, is needed to further clarify this strange difference between younger and older people.
“These results are inconsistent with many large studies showing no harm or no net profit from aspirin,” Campbell said.
The study was published on August 10 National Cancer Institute Journal..
For more information
The National Cancer Institute Aspirin and cancer risk..
Source: Andrew Chan, MD, MPH, Director, Epidemiology, Massachusetts General Hospital Cancer Center, Boston; Frank Sinicrope, MD, Gastroenterologist, Mayo Clinic, Rochester, MN. Peter Campbell, PhD, Scientific Director, Epidemiologic Studies, American Cancer Society; National Cancer Institute Journal, August 10, 2020
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