Health
Research reveals secrets of beta cell regeneration
Professor Heiko Rickert is Director of the Helmholtz München Institute for Diabetes and Regenerative Research, Professor at the Technical University of Munich (TUM) and member of the German Diabetes Research Center (DZD). Together with his team, they discovered the inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both receptors and insulin receptors are located on the surface of beta cells, and receptors can block insulin receptors, making the cells less sensitive to insulin and weakening signaling pathways. Current research goes further and shows that the receptor binds to excess insulin in beta cells, leading to its breakdown. “This knowledge of receptor function provides a deeper understanding of how beta cells regulate insulin homeostasis,” says Heiko Rickert.
Regeneration of damaged beta cells
The increased presence of the receptor in beta cells suggests that this receptor plays a role in insulin secretion regulated by beta cells. This process is often impaired in diabetes, leading to elevated blood sugar levels. By blocking the receptor, the researchers were able to replenish insulin stores in beta cells, stimulate insulin release, and prevent beta cell death.
Blocking the receptor may boost insulin production and protect beta cells, especially in cells that are already damaged. ”
Heiko Rickert, Director of the Helmholtz Munich Institute for Diabetes and Regeneration
Hope for Type 2 Diabetes Patients
This finding suggests that specifically targeting the receptor may be a promising strategy to improve the function of insulin-producing cells. person with diabetes. “Our goal is to build on our findings to develop new drugs that support cellular insulin balance and extend survival,” Rickert said. Such treatments may help slow the progression of the disease and reduce symptoms, especially for people in the early stages of type 2 diabetes. Risk of complications.
From the lab to practice: Starting up a new diabetes treatment
To translate these discoveries from the lab into real-world applications, Likert founded a startup company. The company is working to develop drugs that specifically block receptors to protect or regenerate beta cells. Preclinical studies are first required to test safety and security. efficacy of These new therapeutic approaches. “Our goal is to pave the way for clinical trials and thereby contribute to the treatment, and hopefully cure, of diabetes,” Rickert says.
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Reference magazines:
Seeler, J. others. (2024) The receptor binds insulin and directs it toward lysosomal degradation within β cells. natural metabolism. doi.org/10.1038/s42255-024-01164-y.
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