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Vitamin D supplements: Who should take how much?

Vitamin D supplements: Who should take how much?

 


“The committee spent nearly four years collecting and conducting a systematic review of existing vitamin D research,” Pittas said. “We prioritized randomized controlled trials, which are considered the gold standard in assessing causality. At a time when there were not enough studies of this type, we chose We also turned our attention to longitudinal cohort studies developed in this area.

The researchers used the so-called Grading of the Evidence (GRADE) methodology to rate each study's certainty of evidence (high to low) and the strength of the recommendation, where the benefits clearly outweigh the harms, or whether the recommendation is conditional. evaluated both. The benefits probably outweigh the harms, but there may be individual differences.

We used meta-analysis to see if it may be possible to gather more information for recommendations when data from multiple randomized controlled trials can be combined.

The multidisciplinary committee included adult and pediatric endocrinologists, internal medicine, obstetrics, epidemiology, nutrition, systematic review methodology, and clinical guideline development. Patient representatives also participated. The draft recommendations were subject to external peer review and public feedback.

“This was a really meticulous, evidence-based process,” Pittas said. “By prioritizing randomized controlled trials and using robust, objective methodologies, we ensured that our recommendations were based on the best available evidence.”

Sources

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2/ https://now.tufts.edu/2024/12/02/vitamin-d-supplements-who-should-take-them-and-how-much

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