Health
Keto diet may boost blood cancer treatment, research claims
A new study suggests that a common nutritional supplement may make a type of cancer treatment called CAR-T cell therapy more effective.
This research university of pennsylvania and Penn Medicine's Abramson Cancer Center were shared at a major medical conference, the American Society of Hematology (ASH) 66th Annual Meeting and Exhibition (Abstract 4).
What is CAR-T cell therapy?
CAR-T cell therapy is a cancer treatment that uses a patient's own immune cells to fight cancer. These immune cells are taken from the patient, reprogrammed to attack cancer, and then returned to the body.
Currently, this type of cancer treatment is widely used in the following areas: Only for patients with certain blood cancers.
The role of diet in improving treatment
Researchers tested how different diets affected CAR-T cell therapy in mice with a type of blood cancer.
They found that a ketogenic diet (commonly known as a keto diet), which is very low in carbohydrates and high in fat, improved the tumor-fighting ability of CAR-T cells.
why? On a keto diet, your body produces a substance called beta-hydroxybutyrate (BHB). BHB is a chemical produced by the liver when the body is damaged. Burns fat for energy instead of carbohydrates.
Researchers found that CAR-T cells use BHB as a better energy source than sugar, making them even more powerful at killing cancer cells.
What is the Keto Diet?
The ketogenic diet, or keto diet, is a way of eating that limits carbohydrates (such as bread, rice, and sugar) and focuses on fats (such as ghee, butter, and nuts).
Normally, the body uses glucose (sugar) from carbohydrates for energy. However, when you significantly reduce carbohydrates, your body enters a state called ketosis and starts burning fat for energy instead.
this In the process, molecules called ketones are produced.containing beta-hydroxybutyrate (BHB), which acts as an alternative fuel. Popular for weight loss, the keto diet typically includes foods such as meat, fish, eggs, nuts, dairy products, and healthy fats, and avoids bread, rice, sugar, and starchy vegetables.
test the theory on humans
The research team also studied blood samples from cancer patients and healthy volunteers. They found that increased BHB levels were associated with: Stronger CAR-T cell activity.
In mice, adding a simple BHB supplement helped CAR-T cells completely eliminate cancer in most cases.
What's next?
Clinical trials are currently underway to see if this approach works in people with a type of blood cancer called large B-cell lymphoma. This study will test whether taking BHB supplements can increase the effectiveness of CAR-T cell therapy.
One of the researchers, Dr. Mayan Levy, emphasized that this potential treatment is low cost and has minimal side effects.
However, the research team cautioned that it was too early to make dietary or supplement recommendations. “Further evidence from clinical trials is needed,” they said.
If this simple approach proves effective, it could revolutionize cancer treatment and provide patients with a safe and affordable way to improve outcomes. .
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Sources 2/ https://www.indiatoday.in/health/story/study-claims-keto-diet-can-boost-treatment-for-blood-cancer-2648071-2024-12-11 The mention sources can contact us to remove/changing this article |
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