Health
Colorectal cancer is linked to inflammation – what role does diet play?
- New study finds higher levels of inflammation in colorectal cancer tumors, Suppresses the body's ability to fight disease.
- Although researchers point to the typical Western diet as a culprit in causing inflammation, other studies have linked ultra-processed foods to inflammation.
- Experts recommend limiting or avoiding ultra-processed foods and choosing healthier options like whole grains, fruits, and vegetables to reduce cancer risk.
A new analysis of colorectal cancer tumors shows that they have high levels of inflammation and lack the natural ability to resolve inflammation.
The study was published in the journal Dec. 10 intestinesexamined 162 tumor samples from colorectal cancer patients. This finding indicates that the lipid profile of colorectal cancer tumors exhibits a “clear pro-inflammatory bias.”
Researchers suggest adopting “.solution medicine” is used as a treatment for colorectal cancer to reverse inflammation and restore the body's healing mechanisms. They also note that the typical Western diet is strongly associated with: chronic inflammation and its development and progress colorectal cancer.
Dr. Jeffrey BuckleHe, a gastrointestinal oncologist at UCSF Health in San Francisco, said the findings have the potential to expand knowledge about cancer and inflammation. Buckle was not involved in the study.
“This is an interesting study that looks at inflammatory changes in colorectal cancer and begins to reveal how inflammation occurs in and around tumors,” Professor Buckle said.
“Interestingly, this study also explores how inflammation could be a target for future cancer treatments. This work is interesting and very important. We have long understood the link between inflammation and cancer. Although suspected, little is known about the mechanistic basis of this association. This study adds to a growing body of literature suggesting that inflammation may play an important role in cancer development. ,” he told Healthline.
“Many things can increase the risk of inflammation in the body, and inflammation is the basis of many diseases, including cancer, so find anti-inflammatory approaches to offset inflammation levels (such as limiting ultra-processed foods). ), you should replace them with alternative foods. foods that reduce inflammation It makes sense given the research results.” kristin kirkpatrickA dietitian in the Department of Health and Preventive Medicine at the Cleveland Clinic in Ohio told Healthline. Kirkpatrick was not involved in the new study.
Wael Herb, MarylandA hematologist and medical oncologist at MemorialCare Cancer Institute at California's Orange Coast and Saddleback Medical Centers, who was not involved in the study, says ultra-processed foods can not only improve chronic inflammation but also immunity. It also causes inhibition, “creating an environment where cancer is more likely to occur.'' development and progress. ”
The research published in intestines “We provide strong evidence linking ultra-processed foods (UPFs) to an increased risk of colorectal cancer (CRC) and a reduced ability of the body to fight disease,” Herb told Healthline.
For many years, health experts have said The traditional Western diet that many people in the United States follow can increase the risk of many cancers.
They also noticed The importance of diet before, during, and after colorectal cancer treatment.
“Diet is an important factor, and I would add that diet is also a modifiable risk (different from age, genetics, etc.),” Kirkpatrick said.
“The data shows that the risk of colorectal cancer related to dietary patterns is not just about what you eat on a regular basis, but also about what you limit. Foods that are high in processed red meat Risk may increase. regular physical activity, no smoking, limit alcohol intake It’s also a modifiable factor,” she explained.
Dr. Anton BilchikA surgical oncologist, chief of internal medicine, and director of the gastrointestinal-hepatobiliary program at Providence St. John's Cancer Institute in California, agrees that there are other important factors besides diet. Bilchik was not involved in the study.
“There are several risk factors for the development of colorectal cancer. These include diet, obesity, family history, lack of physical activity, etc. All are important but as yet undefined risk factors. There are probably many more,” Bilchik told Healthline.
Herb agrees. “Diet is an important modifiable risk factor for colorectal cancer, but genetic predisposition, family history, age, smoking, alcohol intakephysical inactivity and obesity also play important roles,” he said. “A comprehensive approach to colorectal cancer prevention must address all of these factors.”
Herb added that it's also important to obey. healthy eating Currently undergoing cancer treatment.
“Maintaining a healthy diet is extremely important during CRC treatment,” he says. “Proper nutrition supports the immune system, increases resistance to treatments, and improves overall health. Patients should focus on easily digestible foods such as: lean proteinEnsure adequate hydration while consuming , certain vegetables, and low-fat dairy products. ”
“Maintaining a healthy, balanced diet is essential during treatment, as the immune system relies on nutrients to eliminate cancer cells and prevent recurrence,” Bilchik added.
Dr. Buckle listed several precautions regarding diet during cancer treatment.
“While we certainly encourage patients to strive for a healthy diet during colorectal cancer treatment, incorporating dietary changes during active cancer treatment can be difficult, at best “We also warn patients that they are likely to receive only a small benefit,” he said.
“Many studies have been conducted on specific diets during cancer treatment, including: ketogenic dietMediterranean diets, and intermittent fasting, research shows signs of benefit, but more research is needed before they can be ready for prime time or adopted as standard of care. Although I encourage my patients to eat a healthy diet, relying on comfort foods can be problematic during treatment, especially when dealing with the side effects of chemotherapy (such as loss of appetite, nausea, and changes in taste). We also tell patients that there is no such thing. ” The buckle attracted attention.
To reduce cancer risk, Kirkpatrick recommended foods high in fiber, including: whole grainfruits, vegetables, and allium family foods such as onions, garlic, and leeks.
Herbs suggest consuming enough fiber, antioxidants every day. “To lower my risk of colon cancer, I eat vegetables, fruits, whole grains, legumesnuts, and lean proteins such as fish and chicken,” he said.
“These foods are rich in fiber and antioxidants, which promote healthy digestion and support your health. intestinal microbiotamay have a protective effect against CRC. “It's also a good idea to limit your intake of red and processed meats, as well as sugary and ultra-processed foods,” Herb added.
“Foods rich in omega-3 fatty acids, such as fruits, vegetables, and salmon, Foods with high fiber content These are all important for reducing the risk of developing colorectal cancer,” Bilchik said.
“We typically recommend that individuals: drink alcohol in moderationavoid tobacco useRed meat and processed meat (sausages, baconham, beef jerkyand other forms of meat that are smoked, cured, fermented, or salted),” Buckle said.
“We recommend a sufficient amount dietary fiber and calcium intake. A diet that includes regular intake of fruits and vegetables is also recommended. ”
Colon cancer is
The American Cancer Society (ACS) notes that colorectal cancer diagnosis and mortality rates have declined in the United States since the 1980s.
ACS attributes this decline to increased screening and adjustments to lifestyle factors. However, they added that most of the decline is occurring among older people, while the proportion among younger people is rising.
At the beginning of this year, reported Early-onset colorectal cancer in adults under age 50 increased from less than 5 per 100,000 people in 1994 to 10 per 100,000 people in 2021.
Current American College of Physicians Recommended People start getting screened for colorectal cancer starting at age 50.
Researchers say chronic inflammation not only increases the risk of colorectal cancer, but also suppresses the body's ability to fight colorectal cancer.
The Western diet, which is high in ultra-processed foods, is a major cause of chronic inflammation.
Experts recommend limiting ultra-processed foods and eating healthier whole foods like whole grains, vegetables, and fruits.
Sources 2/ https://www.healthline.com/health-news/inflammation-diet-colorectal-cancer-risk The mention sources can contact us to remove/changing this article |
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