Pefar and the Global Fund aim to roll out HIV vaccinations

Nearly 2 million people may have access to lenacapavir, a twice-yearly antiretroviral injection that prevents HIV infection, within the next three years, thanks to the Global Fund and the U.S. President's Emergency Plan for AIDS Relief (PEPFAR). do not have.

The initiative is subject to U.S. regulatory approval. Recommendations from the Food and Drug Administration (FDA), national drug regulatory authorities, and the World Health Organization (WHO).

This project is supported by the Children's Investment Fund Foundation (CIFF) and the Bill & Melinda Gates Foundation (BMGF).

Lenacapavir is currently approved in the United States and other countries for the treatment of adults with drug-resistant HIV.

However, two clinical trials have shown that it almost completely blocks HIV when used as pre-exposure prophylaxis (PrEP). Of the 2,138 women, there were none. Objective 1 Trial People who received lenacapavir became infected with HIV.

in Objective 2 Trial With a diverse population of men and gender, only two of the 2,179 participants became infected during the trial, resulting in a success rate of more than 99%.

In both trials, lenacapavir was tested alongside oral PrEP and found that lenacapavir was superior because twice-yearly injections were much easier to adhere to than taking a pill every day.

“We cannot reach a sustainable HIV response unless we rapidly reduce the 1.3 million new HIV infections that occur around the world each year,” Ambassador John Nkengasong, PEPFAR's U.S. Global AIDS Coordinator, said in a statement on Tuesday. mentioned in.

“Lenacapavir will help end HIV/AIDS by ensuring access to highly effective HIV prevention, testing and treatment services for adolescent girls and young women, key populations and other populations who could benefit.” “Provides a potentially significant opportunity to transform the impact of HIV programs as a public health threat by 2030.”

In October, pharmaceutical manufacturers Announced by Gilead The company announced that it has entered into non-exclusive, voluntary licensing agreements with six pharmaceutical companies to manufacture and supply a generic version of lenacapavir primarily to 120 low- and lower-middle-income countries.

“At the Global Fund, we are very excited about the promise of lenacapavir and its potential to further significantly reduce new infections among individuals at high risk of acquiring HIV,” said Peter Sands, Executive Director of the Global Fund.

“As part of this coordinated effort, the Global Fund, PEPFAR, CIFF, and BMGF are collaborating with Gilead and self-licensing manufacturers to foster affordable and equitable access so that more people can benefit from this powerful innovation from day one.” We will make sure that you receive the benefits.”

CIFF founder and chairman Sir Chris Horne said innovations like lenacapabil could have a significant impact on the lives of millions of people.

“It's a travesty if the communities that need it most don't have access. That's why this collaboration is so important to get lenacapavir to the people who need it most as quickly as possible,” Horn said.

Image credits: gilead.

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