Health
Research tracing the route of Ebola virus to the skin surface
It is well known that the Ebola virus is transmitted through contact with the body fluids of infected people, but in recent Ebola outbreaks, the infectious virus has been detected on the skin of people who died from the infection and even in the later stages of infection. Proven. Although there is evidence that the Ebola virus can be transmitted through human skin contact during the later stages of the disease, little is known about how the virus leaves the body and reaches the skin surface. do not have.
In a new study, US researchers traced the cellular pathway the virus uses to cross the inner and outer layers of the skin and emerge on the skin's surface. This study identifies a new cell type in the skin that is targeted by the virus during infection and shows that human skin specimens actively support viral infection. Results announced in scientific progress This suggests that the skin surface may be one route of human-to-human transmission.
Researchers have developed a new approach to find out which cells in the skin are infected with the Ebola virus. They created a human skin explant system using full-thickness skin biopsies from healthy people, including both the deep (dermis) and superficial (epidermis) layers of the skin.
Previous clinical and animal studies have reported that cells within the skin are infected by the virus, but the specific cells targeted by the virus have not been identified. In the new study, the researchers showed that the virus infected several different cell types in the skin explants, including macrophages, endothelial cells, fibroblasts, and keratinocytes. Although some of these cell types are also known to be infected by viruses in other organs, keratinocytes unique to the skin were not previously recognized to support Ebola virus infection.
Interestingly, virus replication per gram was more intense in the epidermal layer than in the dermal layer. Furthermore, infectious virus was detected on the epidermal surface within 3 days, indicating that the virus spreads rapidly and migrates through the explant to the skin surface.
issued – January 4, 2025 10:00 PM IST
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