Health
Science Newsletter New study links loneliness to cardiovascular disease, stroke and death
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new study Published on January 3, 2025 nature human behavior The journal found that loneliness and social isolation in humans may be associated with cardiovascular disease, stroke, and mortality.
The study was conducted by researchers from Fudan University in Shanghai, China, and the University of Warwick in the UK. They looked at data from 42,062 people, with an average age of about 56 years, and analyzed 2,920 proteins in their blood samples. The researchers also tracked the participants' health data for 14 years.
The researchers analyzed the subjects' protein levels and how they expressed themselves, looking for correlations with social isolation and loneliness. With this study, the researchers wanted to answer two questions:
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Which proteins are associated with social isolation and loneliness?
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How do they contribute to the relationship between social isolation, loneliness, and health?
This is what they found.
Researchers found that a protein that is an inflammatory marker and not normally expressed in tissues showed the strongest association with social isolation, while another protein that regulates blood cholesterol levels was strongly associated with loneliness. I paid attention to that.
The study used Mendelian randomization (MR), a scientific method that uses genetic variation (and therefore protein structure) to establish causal relationships between variables. Overall, we found that loneliness contributed to increases in five specific proteins. These proteins have shown associations with the volume of brain regions associated with metabolic processes and blood components such as cholesterol levels and lipid profiles, as well as the ability to sense physiological states and emotional and social processes within the body. Ta.
The researchers established a mediating effect between loneliness and cardiovascular disease, stroke, and mortality through these proteins identified by MR. For example, a one-unit increase in one of these proteins increases the risk of death by 58%. The overall results of the study support the hypothesis that social relationships indirectly influence morbidity and mortality.
However, the researchers found that although a causal link of loneliness to five specific proteins was observed using multiple analytical methods, one genetic variation can affect multiple traits through related pathways, confounding the results. He also pointed out that there is a possibility. This is a common problem in MR studies, and further investigation in larger datasets is required to know whether the associations observed in this study are due to direct causality.
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issued – January 8, 2025 5:22pm IST
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