A strong ally in the fight against Alzheimer's disease

Regular aerobic exercise can significantly reduce disease markers associated with Alzheimer's disease, a study led by scientists at the University of Bristol (UK) and Federal University of São Paulo (Brazil) has found. This discovery brings new hope in the fight against this devastating disease.

Published in a magazine brain research, study It highlights how physical activity not only protects healthy brain cells, but also restores balance to the aging brain.

The study focused on the hippocampus, a brain region responsible for memory and learning, and measured its effects. aerobic exercise About the main Alzheimer's disease markers: amyloid plaquestau tangles, and iron accumulation in myelin-producing cells known as oligodendrocytes. These markers play a central role in Alzheimer's disease.

The findings revealed that rodents who completed a structured aerobic exercise program experienced:

• Tau tangles (approximately 63% with exercise) and amyloid plaques (approximately 76% in adults) are significantly reduced. exercise group), iron accumulation (decreased by approximately 58% in the brains of exercising rodents).
• Brain cell health is enhanced, including an increase in the number of protective oligodendrocytes.
• reduction in brain inflammation in the exercise group (between 55% and 68% depending on the inflammatory biomarkers considered), and cell death.
• Improves communication between brain cells and restores the important balance in brain function associated with aging.

Dr Augusto Coppi, Senior Lecturer in Veterinary Anatomy at the University of Bristol and one of the study's senior authors, said: 'Alzheimer's disease is a progressive neurodegenerative disease with no known cure, It affects millions of people. Physical exercise is known to reduce symptoms. Decline in cognitive functionthe cellular mechanisms behind its neuroprotective effects remain elusive to date.

“This study highlights the potential for aerobic exercise to be a cornerstone of Alzheimer's disease prevention strategies.”

Key findings from the study include:

• Incorporating regular aerobic exercise into daily life may play an important role in slowing or preventing the progression of Alzheimer's disease.
• Public health efforts must prioritize exercise programs tailored to aging populations.

Researchers are currently planning human clinical trials We confirm the protective effects observed in rodent models. They also plan to study drugs that target iron metabolism and cell death as potential treatments for Alzheimer's disease.

Detailed information:
RC Gutierre et al., Tau, amyloid, iron, oligodendrocyte ferroptosis, and inflammation in the hippocampal formation of aged rats subjected to an aerobic exercise program, brain research (2024). DOI: 10.1016/j.brainres.2024.149419

Provided by
University of Bristol

quotation: Aerobic exercise: A powerful ally in the fight against Alzheimer's disease (January 16, 2025) From https://medicalxpress.com/news/2025-01-aerobic-powerful-ally-alzheimer.html January 2025 Retrieved on 16th

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