Health
Research shows that HPV16 treatment vaccine is safe and effective for eradicating pre -cancer lesions.

The treatment treatment vaccine VVAX001 is known to be safe, and has a preliminary clinical effect on the II phase clinical trial of HPV16 positive grade 3 internal tumor tumor patients. If it is confirmed in the III Phase Examination, the vaccine may provide a non -surgene option for a prenatal cervical lesion. Research by EERKENS and others is published in Clinical cancer research。
the study Long -term infections with high -risk human papaparomavirus (HPV), including HPV16 and HPV18, indicate that all cervical cancer is substantial. Previous VVAX001, a phase a clinical trial of VVAX001, a treatment vector vaccine targeting E6 and/or E7 proteins, induces powerful anti6 and -E7 cell poisonous T cell response to patients. Understood. The VVAX001's II tests showed that the vaccine was safe and showed a spare clinical effect on 18 patients with HPV16 -positive grade 3 cervical tumnular tumor. If it is confirmed in the III Phase Examination, the vaccine may provide a non -surgene option for a prenatal cervical lesion.
Research methodology
Researchers have registered a total of 18 patients with a newly diagnosed HPV16 -positive grade 3 intra -skin tumor (CIN3). The patient received three VVAX001 vaccinations at three weeks. Patients were monitored about Cin3 regression by Corposcopy until 19 weeks after the last vaccination. Corposcopy induction biopsy was collected at the time of the previous visit, and standard care loop resection was performed only when CIN2/3 remains.
The organization pathological reaction rate, HPV16 clearance, treatment -related adverse events, and vaccine -induced immune response were evaluated.
result
The Corpos Copy test has found a decrease in CIN3 lesion size for 17 (94 %) of 18 patients (94 %), which had already been revealed after three weeks after the last vaccination. Nine of the 18 patients (50 %) are observed with an organizational pathological perfect response (no regression to Cin1 or no different formation), and 10 out of 16 patients (63 %) have HPV16 clearance. It was observed. Vaccines did not induce other HPV clearance.
Until now, researchers have observed the recurrence, each of which is 20 months and 30 months without the median and the longest illness. No serious adverse events were observed.
“VVAX001 treatment is secure and feasible, and it shows a preliminary clinical effect in patients with HPV16 -related CIN3 lesions,” concluded the research author.
Importance of translation
“As far as we know, this reaction rate will be one of the most effective treatment vaccines for HPV16 related CIN3 lesions reported so far.” Refika Dist, MDHe is a chief researcher of this research and a tumor and gynecologist at GRONINGEN, a Dutch university medical center. “If you have been confirmed in a larger test, our results may be that at least half of Cin3 patients may omit surgery and avoid all possible side effects and complications. “
Dr. Igit, the Dutch University Medical Center Groningen, is the author of this study.
Disclosure: Funds for this study were provided by the Dutch Cancer Association and Vicinivax. You may find the conflict statement of the research author aacrjournals.org。
Sources 2/ https://ascopost.com/news/january-2025/study-finds-therapeutic-vaccine-targeting-hpv16-is-safe-and-effective-in-eradicating-precancerous-cervical-lesions/ The mention sources can contact us to remove/changing this article |
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