Health
Alcohol and existing health conditions increase the risk of advanced liver disease
Why do some people consume several glasses of alcohol a day, while others develop advanced liver disease and drink the same amount?
This answer is based on a new study published in Clinical Gastroenterology and Hepatology From Keck Medicine at USC. The study found that heavy drinkers, either diabetes, hypertension, or around the high waist, were 2.4 times more likely to develop advanced liver disease.
The results identify very high risk segments of the liver disease prone population, suggesting that existing health issues can have a major impact on how alcohol affects the liver . ”
Brian P. Lee, MD, MAS, liver specialist and liver transplant specialist Keck Medicine and research principal investigator
Diabetes, hypertension, obesity-related diabetes, hypertension, and high waist circumference (40 inches for women) affect the risk of cardiac attack and stroke risk known as cardiac metabolic risk 5 Factors belonging to two health conditions clusters.
Risk factors for cardiac metabolism are associated with liver fat accumulation (also known as metabolic dysfunction-associated fatty liver disease), which can lead to fibrosis and liver scarring. These risk factors affect more than one in three Americans, and according to Lee, it has worsened cardiac metabolic health, especially among people under the age of 35.
Alcohol also causes liver fat accumulation, which has seen an increase in alcohol consumption since the COVID-19 pandemic, Lee said. Both the prevalence of cardiac metabolism risk factors and alcohol consumption in the US, Lee and his fellow researchers investigate which cardiac metabolic factors predispose the liver to alcohol-induced damage. I took on the research to do so.
They analyzed data from the National Health and Nutrition Survey, a large national survey of over 40,000 participants. Serious liver fibrosis refers to liver scars that can lead to liver failure.
In this study, heavy drinking was characterized by 1.5 drinks per day in women (20 grams) and 2 drinks per day in men (30 grams).
Researchers found that heavy drinkers, either diabetes or around the lower back, are 2.4 times more likely to develop advanced liver disease and 1.8 times more likely to develop advanced liver disease, and those with hypertension. They have shown that two other cardiac metabolic risk factors – high triglycerides (higher levels of fat types in the blood) and low HDL (high density lipoprotein or “good” cholesterol) are significantly correlated with liver disease. I discovered there were few.
Although this study did not analyse why these three cardiac metabolic factors are more dangerous to the liver, Lee speculates that these conditions share a common pathway to liver fat accumulation. I'm doing it. Serious damage.
Lee stresses that this study does not mean that it is safe for people without these three cardiac metabolic risks to consume large amounts of alcohol. “We know that alcohol is toxic to the liver and that all heavy drinkers have a risk of advanced liver disease,” he said.
Lee hopes the findings encourage people to consider their individual health and risk profiles when making decisions about alcohol consumption. He also hopes that practitioners will provide personalized health screenings and interventions by people who drink at risk factors for cardiac metabolism so that liver damage between this high-risk group can be caught and treated early. Masu.
Norah Terrault, MD, Keck Medicine Gastroenterologist and Head of Gastroenterology and Liver Diseases at Keck School of Medicine, was also the study author.
sauce:
Journal Reference:
Lee, BP, et al. (2025). Relationship between alcohol, progressive cardiac metabolic risk factors and liver disease: a national cross-sectional study. Clinical Gastroenterology and Hepatology. doi.org/10.1016/j.cgh.2025.01.003.
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