Health
US developing coronavirus strains for human “challenge” trials
US government scientists are considering deliberately infecting a volunteer with a new strain of coronavirus to test the vaccine more quickly
According to government agencies, US scientists are developing a coronavirus strain that can be used to deliberately infect volunteers in so-called “challenge studies.”
Work is preliminary and the government continues to prioritize randomized clinical practice trial of vaccine The candidate, the National Institute of Allergy and Infectious Diseases (NIAID) said.
Some of these have entered the final stages, including the vaccine developed by Moderna, Pfizer and AstraZeneca.
However, nevertheless, NIAID “has started an effort towards the production of strains that can be used for human development. Challenge Model, if necessary,” said the statement.
In a typical clinical trial, volunteers receive either drugs or placebo and follow their health over the next few months.
Scientists look for how well a vaccine or treatment works when a person is naturally exposed to a pathogen.
A faster way to test whether a drug works, as it has been in the past with influenza, malaria, and typhoid fever, is to deliberately infect volunteers. Dengue fever,cholera.
In the United States, Advocacy group While 1Day Sooner supports the COVID-19 challenge study, this issue is controversial as the disease is so severe and its effects are not fully understood.
The NIAID said a decision could be made towards the end of 2020, when ongoing late-stage clinical trials will begin reporting results.
This added that challenge studies were needed and helped determine if they were safe and ethical.
David Diemart, director of George Washington University’s vaccine trial research unit and overseeing the trial of Moderna’s vaccine in the U.S. capital, told AFP he didn’t think the challenge trial was appropriate for COVID-19. It was
“I think they are important tools, but only under the right circumstances,” he said.
Diemart himself leads a challenge trial for the hookworm vaccine.
However, for COVID-19, “There is no clear understanding of who is at risk of developing a serious illness, and no cure is guaranteed to cure someone if they develop a serious illness.” “
It is also the worst-hit country in the world with 5.3 million confirmed cases, with widespread community transmission in the United States. In other words, no challenge trial is needed.
© 2020 AFP
Quote: Coronavirus strains under development for US human “challenge” trials (August 15, 2020) are: August 15, 2020, https://medicalxpress.com/news/2020-08-coronavirus- Retrieved from strain-human-trials.html
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