Health
SARS-CoV-2-specific T cell immunity may prevent reinfection with COVID-19: a study
According to this study, SARS-CoV-2 specific T cells are also found in families of people exposed to the virus who test negative for blood antibodies. These cells were also found in convalescent individuals with an asymptomatic history. COVID infection.
Strong reaction
All categories of people who recovered from moderate to severe COVID 19 infections, were in convalescence after mild or severe illness, or were exposed to the family were asked to “count post-infection, even in the absence of detectable circulation. An antibody specific for “SARS-CoV-2” that showed a strong memory T cell response over months claims research.
Scientists were able to detect similar memory T cell responses to internal and surface proteins of the virus in people for whom SARS-CoV-2 specific antibodies were not detected.
This means that serum prevalence as an indicator may underestimate the degree of immunity in a population, eg scientists.
“The dissociation of the antibody (its absence) and the robust T cell response are notable. By focusing on antibodies for convenience, we focus on antibodies because T cell responses are only evaluated in the laboratory. It is reinforcing how much you missed.
Studies have shown that once infected, even animals were fully protected from reinfection. To date, no cases of reinfection have been detected worldwide, whether they recovered from a mild or severe COVID infection or were completely asymptomatic.
Antibodies may not be detected in people who have mild symptoms or who are completely asymptomatic. At the same time, it was found in humans infected with SARS-CoV-2 specific T cells.
the study
The team of researchers characterized 206 different T cells, including those who recovered from moderate or severe illness, convalescent individuals, and healthy blood donors.
Due to the small size of this study and its limited clinical follow-up, it cannot be fully argued that a robust memory T cell response could protect against severe COVID 19 infection. However, the 2002 SARS and MERS elicited strong memory T cell responses that persist even when the antibody response declines.
As the antibody declines over time, the strong T cell memory formed after SARS-CoV-2 infection maintains a strong adaptive immunity and protects it from severe reinfection with the virus.
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