Health
Semaglutide slightly increases the risk of optic nerve damage
Use of semaglutide in patients with type 2 diabetes (T2D) slightly increases the risk of Nonsomatic anterior ischemic optic nerve disorder (naion)Research published in Jama Eye Clinic show. This study utilized observational medical data science and informatics (OHDSI) networks. This is an international open science collaborative collaboration centered on the Observation Medical Outcomes Partnership (OMOP) Common Data Model (CDM), which investigated the association between semaglutide use and Naion.
Researchers found that the use of glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide is associated with a risk of more than four times as much as NAION compared to non-GLP-1RA. Researchers in the current study further evaluated its tie by analyzing data from several databases aimed at determining whether the risk of Naion is greater in Semaglutide, other GLP-1RA, or non-Glp-1RA. Weight loss drugs (Empagliflozin, Sitagliptin, and Glipizide).
Using active comparator cohort design and self-control case series (SCCS) analysis, investigators reviewed data from 37.1 million adults with type 2 diabetes (810,390 new Semaglutide users) from December 2017 to 2023. To meet the criteria for sensitive definitions of the study, patients needed a 1 ischemic neuropathy diagnostic code. To obtain criteria for specific definitions, patients Ischemia The optic neuropathy diagnosis code must be checked within three months.
Researchers found that the incidence of NAIONs in new semaglutide recipients was 14.5 per 100,000 person-years based on confidential definitions and 8.7 per 100,000 person-years based on a specific definition. Investigators found that the percentage of Naion incidence among new semaglutide recipients was 7.1 per 100,000 people in the confidential definition and 4.2 per 100,000 people under the specific definition.
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We were able to identify an increased risk of Naion, even when the ineffective semaglutide preparations were included.
Based on sensitive and specific definitions, Naion risk was similar for semaglutide use compared to duraglutide use or non-Glp-1RA drug use. 1 exception: By a particular definition, the Naion risk was 2.27 times the new recipient of Semaglutide compared to the Empagliflozin recipient.
The self-control case series analysis identified a maximum of 39,104 patients on NAION based on confidential definitions and 22,005 patients on specific definitions. The incidence of naion was greater due to semaglutide exposure, regardless of whether the researchers applied sensitive or specific definitions. [IRR]1.32; specific IRR, 1.50). Exenatide was linked to a high incidence rate only by certain definitions (IRR, 1.62; p = .04).
“In OMOP CDM, drugs are identified by their active ingredients. Therefore, the semaglutide group contained subcutaneous injections (ozempic [Novo Nor-disk]) and the formulation of the mouth (Libersus [Novo Nordisk]), the researcher explains. “The subcutaneous form of semaglutide has greater bioavailability, greater efficacy in glucose reduction, and is more commonly prescribed. Even when the effect is low Segurtide We were able to identify increased risks for Naion. ”
Disclosure: Some research authors have declared partnerships with biotechnology, pharmaceuticals, and/or device companies. See the original reference for a complete list of disclosures.
This article was originally published Ophthalmology advisor
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