Washtenau will become Michigan's 15th county with CWD-positive wild deer

Systematic Reviews and meta-analysis Discovered an astonishing level of antibiotic resistance Salmonella In Pakistan, researchers reported yesterday Open Forum Infectious Disease.

The review, led by researchers at Peshawar University, analyzed 31 studies containing data on antibiotic susceptibility in human isolates. Salmonella Typhi and Salmonella Both paratyphi enter the body through contaminated food and water, and is the main cause of typhoid fever and peritoneum. Drug resistance Salmonella Considered by the World Health Organization as a global public health priority, Pakistan has emerged in recent years as a hot spot for multi-drug meat and widespread drug resistance (MDR and XDR) s Typhi.

Significant resistance to commonly used antibiotics

Data from 31 studies revealed significant resistance rates to commonly used antibiotics s Typhi containing nalidixic acid (92%; 95% confidence intervals [CI]88% to 95%), ampicillin (80%; 95% CI, 66% to 89%), ciprofloxacin (64%; 95% CI, 48% to 77%), azithromycin (7%; 95% CI, 3% to 16%), and Meropenem (2% Ci, zero above 1%). The resistivity was also high s Paratyphi: nalidixic acid (91%; 95% CI, 82%-96%), ampicillin (34%; 95% CI, 21%-50%), ciprofloxacin (51%; 95% CI, 25%-77%), azitromachine (4%; 95% CI, 1%-12%), CI, 1%-5%).

in s Typhi, 29% and 25% of patients were found to have MDR and XDR isolates, respectively, but 9% of patients have MDR s Paratyphi infection and 2% had XDR.

The study authors say the findings highlight the urgent need for Pakistan's latest treatment guidelines and public health strategies, which has the third highest typhoid rate in the world.

“Vaccinations, improved access to clean water and sanitation, and reasonable use of antibiotics are key components of the public health response to this increasing threat,” they write. “Continued research, policy interventions, and national and international cooperation are essential to protecting public health and ensuring effective management of intestinal fever in Pakistan and beyond.”

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