Health
UCLA discovers the first stroke rehabilitation drug to reestablish brain connections in mice
Key takeout
- Researchers at UCLA have identified the loss of brain connections that strokes produce.
- The UCLA team discovered that some of the connections lost after a stroke occur in cells called palmi neurons.
- Researchers have found that a drug called DDL-920, developed at Dr. Valghese John's UCLA Lab, leads to significant recovery in motor control in mice.
A new study by UCLA Health found that researchers were the first drug to fully replicate the effects of physical stroke rehabilitation in model mice.
Survey results, We tested two candidate drugs that originated from a study published in Nature Communications on the mechanisms of brain effects of rehabilitation.
Stroke is the main cause of adult disorders, as most patients do not fully recover from the effects of stroke. There are no drugs in the field of stroke recovery, and stroke patients should undergo physical rehabilitation, which has been shown to be modestly effective.
“The goal is to have medications that allow stroke patients to take medicines that will produce rehabilitation benefits,” the doctor said. S. Thomas Carmichaellead author of the study, professor and chairman of UCLA neurology. “Post stroke rehabilitation limits the actual effectiveness of post-stroke rehabilitation because it cannot maintain the rehabilitation intensity required for stroke recovery.
“In addition, stroke recovery is different from most other medical fields where medications can be used to treat diseases such as heart disease, infections, and cancer,” Carmichael said. “Rehabilitation is a physical medicine approach that has been around for decades. We need to move rehabilitation into the age of molecular medicine.”
In this study, Carmichael and his team sought to determine how physical rehabilitation improves brain function after a stroke and whether it could produce drugs that could produce these same effects.
Working in laboratory mouse models of stroke and stroke patients, UCLA researchers have identified loss of brain connections where stroke is far from the site of stroke injury. Brain cells far from the site of stroke are cleaved from other neurons. As a result, the brain network does not fire together for movement, walking, etc.
The UCLA team discovered that some of the connections lost after a stroke occur in cells called palmi neurons. This type of neuron helps to produce a brain rhythm called gamma oscillations. It is called gamma vibration. This allows neurons to join together to form a coordinated network to generate actions such as movement. A stroke causes the brain to lose gamma vibrations. Successful physical rehabilitation in both laboratory mice and humans restored gamma oscillations to the brain, and in a mouse model, repaired the lost connections of palmi neurons.
Carmichael and his team then identified two candidate drugs that could produce gamma oscillations after a stroke. These drugs work specifically to excite palmi neurons.
Researchers found that DDL-920, one of the drugs developed at Dr. Varghese John, who co-authored the study, led to a significant recovery in motor control in mice.
This study has two major areas of impact. First, we identify the brain substrates and circuits underlying the effects of brain rehabilitation. Second, this paper identifies unique drug targets in the brain circulation of this rehabilitation, and promotes recovery by mimicking the main effects of physical rehabilitation.
Further research is needed before examining the safety and efficacy of DDL-920 in human trials.
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Sources 2/ https://newsroom.ucla.edu/releases/ucla-discovers-first-stroke-rehabilitation-drug-to-reestablish-brain-connections-in-mice The mention sources can contact us to remove/changing this article |
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