Health
Pregnant mother’s immune status is associated with behavioral and emotional problems in children with autism
Autistic children born to pregnant immune mothers are more likely to have behavioral and emotional problems, a study by UC Davis Health found. This study examined maternal immunity history as a predictor of symptoms in children with autism.
We tested the ability of the maternal immune history to predict the possible role of ASD symptoms and offspring sex. “
Paul Ashwood, Professor and Professor of Microbiology and Immunology at UC Davis MIND Institute
Published on August 14 Translation PsychiatryThe study found that the sex of the child can also interact with the immune status of the mother, affecting results, especially in terms of the child’s cognition.
Maternal immune status and autism
Maternal immune status is caused by dysfunction of the mother’s immune system. They include allergies, asthma, autoimmune diseases, autoinflammatory syndromes and immunodeficiency syndromes. Previous studies have shown that maternal immune status is more common in mothers of children with autism spectrum disorders (ASD).
The researchers enrolled 363 mothers and their children (252 men, 111 women) in the Autism Phenomenon Project (APP) and Neurodevelopment Autism Imaging (GAIN) study at the UC Davis MIND Institute. did. The median age of children was 3 years.
Researchers measured the severity of autism in children and evaluated a range of behavioral and emotional problems such as aggression and anxiety. They also measured child development and cognitive function.
The study found that about 27% of pregnant mothers were immune. 64% of these mothers report a history of asthma, the most common immune state. Other frequent conditions include Hashimoto’s thyroiditis (hypothyroidism), Raynaud’s disease (blood circulation disease), alopecia (hair loss), psoriasis (skin disease), rheumatoid arthritis (joint tissue inflammation). ..
The study also found that maternal immune status was associated with increased behavioral and emotional problems, but not cognitive decline in autistic children.
Does Offspring Gender Interact with the Impact of Maternal Immune Status on Autism Symptoms?
According to the Center for Disease Control and Prevention (CDC), ASD is four times more common among boys than among girls.
“Our study investigated whether sex of offspring could interact with the presence of maternal immune status to influence behavioral outcomes in autistic children,” Ashwood said. .. “Mother’s immune status may be one of the environmental factors contributing to the increased prevalence of men with ASD.”
The study found that a history of maternal immune status was more common in boys with ASD (31%) compared to women (18%). Specifically, asthma was twice as common in mothers of boys with ASD than in girls with ASD.
Studies have also shown that in the case of ASD, where a maternal immune status exists, female offspring are less susceptible to adverse cognitive outcomes in response to maternal inflammation than male offspring.
“This important finding links the sex of the offspring and the immune status of the mother to autism,” Ashwood said. “It provides more evidence that male offspring are at increased risk of adverse consequences due to maternal immune activation as compared to female offspring.”
Future studies will include identifying the type of immune status, severity, timing of pregnancy, and then examining the progeny results over time.
Source:
See journal:
Patel S. other (2020) Maternal immune status is increased in men with autism spectrum disorders and is not associated with behavioral and emotional but cognitive comorbidities. Translational psychiatry. doi.org/10.1038/s41398-020-00976-2..
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