Health
Drugs used for rare genetic disorders kill mosquitoes that are capable of malaria infection
Nishitoninone, a drug already used to treat rare genetic disorders such as tyrosinemia type 1, blocks mosquitoes, essential enzymes needed to digest blood diets, leading to rapid death.
The new findings are based on Liverpool Tropical Medicine School (LSTM) A groundbreaking 2021 research We have verified the effectiveness of Nitisinone against Tsetse flies.
Published in Science Translation Medicine This week, this new LSTM-driven study reveals the remarkable ability of Nishitoninone to kill both insecticide-sensitive and resistant mosquito strains at doses that were much lower than initially thought.
These findings represent major advances in the fight against malaria and provide a promising new vector control strategy at a critical time when growth in insecticide resistance threatens advances in global disease management.
Dr. Lee Haines, a first author of LSTM, honorary fellow and currently an associate professor at the University of Notre Dame, is a new mode of action against blood-feeding insects, such as mosquitoes. Unlike traditional insecticides that target the mosquito's nervous system, Nisitinone offers mosquito growth. resistance”.
Nichinon works much faster and remains effective longer than another proven mosquito drug, ivermectin, and kills older mosquitoes that usually carry malaria parasites.
Professor Alvaro Acosta-Serrano studied at LSTM and is currently studying at Notre Dame University, USA. Important when applied on-site for safety and economic reasons. ”
“Elderly female mosquitoes are the leading transmitters of malaria parasites. These mosquitoes often endure new mosquitoes to deal with well-durable treatments,” said Dr. Anna Tolett, a PhD graduate who graduated from LSTM in 2025 and now works at the Clinton Health Access Initiative.
Further safety research is needed at various dosage levels, especially in healthy populations in endemic malaria countries, to see if the drug interacts with antimalarial drugs and can truly be reused for malaria control.
Professor Giancarlo Biagini, vice-president of LSTM's research and innovation and co-author of the paper, said, “This innovative research exemplifies LSTM's commitment to translational, interdisciplinary research that promotes real-world impact. While LSTM is an extensive network of pre-clinical and clinical platforms and partnerships, these findings are highly promising, yet more rigorous assessments are essential before NITIONINONE is implemented in public health programs.
This study was conducted by co-author Dr. Ghaith Aljayyoussi, Argentina's Nacional De La Plata Universal De La Plata, University of Glasgow, LSTM scientists including drugs from malaria ventures.
This research has also been made possible thanks to the quality collaboration between Royal Liverpool University Hospital and its National AKU Centre.
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