Health
Essential immune cells in the intestine cause intestinal inflammation and cause an allergic reaction to food when not present
The researchers have identified essential immune cells in the intestines prevent unjust attacks on harmless food allergens. These findings have been published in cell And we demonstrated that in the absence of these cells, subjects experience intestinal inflammation and an allergic reaction to food in the mouse model.1
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The intestinal immune system recognizes enemy friends, tolerate many foods while destroying invaders that cause disease, and explained investigators. For around 30 million individuals in the US with food allergies, which are around 4 million children, immune cells can misidentify food as a threat, causing potentially life-threatening reactions. The most common food allergens include peanuts and tree nuts, shellfish, milk, eggs, and more.2
Specifically, the intestinal immune system maintains resistance to harmless food proteins and gut microbiota via peripherally derived RORγt+ According to the authors, Tregs (Ptregs) prevent food intolerance and inflammatory bowel disease. They explained that the study shows RORγt+ Antigen presenting cells (APCs), including rare dendritic cells (DC) subsets and type 3 innate lymphocytes (ILC3S), may be key to PTREG induction. In their study, we developed mice with reduced RORγt+ Delete Specific APCS Sis– Regulatory elements orc Encoding RORγt to investigate the role of RORγt+ PTREG-induced APC in response to food antigens mimicking oral antigens.1
During the investigation, researchers treated the mice with oval form, a highly allergic protein found in egg whites. Mice lacking intestinal RORγT+ dendritic cells showed signs of allergic lung inflammation, whereas subjects with these cells did not. Furthermore, analysis of intestinal immune cells determined that there is a current imbalance between T cells that cause immune responses to food particles in allergic mice that are skewed to the former.1,2
“We are seeing a rapid global rise in food allergies that have a major impact on quality of life,” said Marco Colonna, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, MD, “The lack of therapeutic agents to prevent and manage food allergies complicate growing public health issues. Knowing players establishing resistance to food allergens, we can devise innovative strategies to prevent or treat them therapeutically and potentially food allergies.”2
Furthermore, lineage tracking revealed RORγt+ DC shares lymphoid origin with ILC3. This is consistent with similar phenotypic properties. These findings highlight the role of lymphatic RORγt.+ Investigators say DCs maintain immune balance in the intestines and prevent conditions like food allergies.1
“By removing RORγt+ Dendritic cells from the intestines of mice, we have broken resistance to food allergens,” postdoctoral scholar Dr. Patrick Rodriguez said in a news release. From RORγt+ Dendritic cells are found in humans, and our findings show exciting new possibilities for managing food allergies and other bowel-related immune diseases, such as celiac disease and inflammatory bowel disease. ”2
The authors highlighted RORγt, but noted that the findings+ The mechanisms that DC, as a key to PTREG induction and dietary antigen resistance, promote TH2 dysregulation and inflammation are not yet clear. Therefore, future studies are needed to further investigate dietary antigen exposure, the spatial dynamics of RORγt.+ Interactions with DCs and food allergens. On the lymph origin of RORγt+ Further verification performed in DCS, in vivo transfer experiments is also required. However, these studies are considered challenging because of the “rareness of precursors,” the authors write.1
“We are targeting RORγt activities.+ Stitong Wu, an MD/PhD student in Colonna's lab, could provide treatment that supports this small cell activity if it proves true, and dendritic cells could work further upstream to prevent the immune response from being triggered first.2
reference
1. Rodrigues PF, Wu S, Trsan T, et al. RORγT-positive dendritic cells are required for the induction of peripherally regulated T cells in response to oral antigens. cell. 2025. doi: 10.1016/j.cell.2025.03.020
2. Washu drugs. Researchers have discovered that intestinal immune cells prevent food allergies. News release. April 3, 2025. Accessed April 15th, 2025. https://medicine.washu.edu/news/researchers-find-intestinal-immune-cell-prevents-food-allergies/
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Sources 2/ https://www.pharmacytimes.com/view/essential-immune-cells-in-intestine-causes-gut-inflammation-allergic-responses-to-foods-when-absent The mention sources can contact us to remove/changing this article |
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