Health
Allergy, asthma and COPD treatment pave the way for development
To gain insight into type 2 immune responses (immune responses associated with allergies, asthma, and chronic obstructive pulmonary disease), scientists at Rutgers University explore helminths, a parasite that spreads to humans from contaminated soil. Checking it up. Worms are generally not welcome. In addition to causing infections, they can mount an uncontrolled type 2 immune response. Worms, however, can prevent the development of inflammatory disease states when given in controlled doses. In fact, parasites are also used to treat irritable bowel disease, ulcerative colitis, and even allergies.
Rutgers Steam, led by associate professor Mark C. Siracusa, recently demonstrated how the type 2 immune response contributes to the expression of neuromedin B (NMB), a neuropeptide that can prevent excessive immune response and damage to inflammation. I investigated. Syracuse and his colleagues detailed the results in an article (“Basophils stimulate group 2 innate lymphoid cells for neuropeptide-mediated inhibition)) appeared on August 14 Natural immunology..
This article describes how NMB reflects a long association between helminths and mammals. In short, this article considers whether the worm “taught” the immune system of hosts, including humans, so that the worm does not overreact. This article also examines whether research on the immune system affected by helminths is relevant to the search for therapeutics for inflammatory diseases.
“In the absence of basophils, the helminth-induced response of group 2 innate lymphocytes (ILC2) has been shown to be exaggerated, resulting in increased inflammation and reduced lung function. “The authors say. “In addition, ILC2 in basophil-depleted mice shows reduced expression of NMB receptors.”
This article highlighted this important point: “NMB stimulation inhibits ILC2 responses from controls but not basophil-depleted mice, and basophils directly enhance NMB receptor expression on ILC2.” It was enough.” This article also points out that NMB proteins can stop the types of inflammation that occur in diseases such as asthma, allergies, chronic fibrosis, and COPD.
“For many years, the mechanisms that block the inflammatory response that the body heals after worm infection remain poorly understood,” says Mark C. Siracusa. Natural immunology paper. “Our research provided an understanding and hope for treatments with NMB that have great potential for the treatment of inflammatory diseases such as asthma, allergies and COPD.”
COPD is the third leading cause of death among inflammatory diseases and allergies, and the sixth in the United States.
“Scientists previously thought that the immune system could regulate itself to resolve inflammation and prevent tissue damage,” Syracuse said. “But new research is beginning to show that complex interactions between the immune and nervous systems act to limit inflammation and promote health.”
The Patent Cooperation Treaty (PCT) patent application was filed by the Rutgers Office of Research Commercialization. The next step for researchers is to use this protein to develop drugs to treat diseases such as asthma, COPD, and allergies.
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