Health
Researchers investigate new targets for potential drugs against COVID-19
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New research has identified some of the SARS-CoV-2 coronaviruses that can be targeted by drugs that interfere with viral replication. This is an important step in developing new, more effective drug therapies.
“This study Molecular process What the coronavirus uses to control how it is made Viral protein It needs to duplicate itself, called frame shifting,” explained Michael Woodside, a professor at the University of Alberta Physics Department and co-author of the study.
“One of the products of frameshift is Virus The frameshift used to replicate itself is a promising target for potential pharmaceuticals. “
Researchers compared the frameshift of SARS-CoV-2 to the same process of its close cousin, the coronavirus that caused the outbreak of SARS in the early 2000s. Their results indicate that both the frameshift genetics and structure are the same for both viruses.
“This study is important. We learned that what we learned about the frameshift of the original SARS virus could be applied to the new coronavirus, and we provide proof of principle that small molecule drugs can knockdown the frameshift.” Wood side.
“We have plans for the future to see if this compound is also effective in suppressing viral replication. The effect is not strong enough to make a good drug, but something Will tell you what to look for. medicine“
The collaborators of this study were John Dinman, a professor of cell biology and molecular genetics at the University of Maryland College Park, who completed frameshift mutagenesis and cell-based studies and conducted X-ray scattering studies. Includes completed Cornell University Loispolak. Measurement of pseudo-knot structure.
The study “Structural and Functional Conservation of the Programmed -1 Ribosomal Frameshift Signal of SARS Coronavirus 2 (SARS-CoV-2)” Journal of Biological Chemistry..
Jamie A. Kelly et al. Structural and functional conservation of the programmed -1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2), Journal of Biological Chemistry (2020). DOI: 10.1074 / jbc.AC120.013449
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University of Alberta
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