Health
Increased fructose intake during pregnancy may affect the metabolism of offspring
Increased fructose intake during pregnancy can cause significant changes in maternal metabolic function and breast milk composition, potentially altering the metabolism of offspring, researchers at the University of Otago in Wellington found.
A study led by Dr. Clint Gray, a pediatrics researcher, found that increasing fructose in a female guinea pig diet resulted in highly significant and consistent changes in circulating free fatty acids in the blood. Of their descendants. This was despite the fact that the offspring did not consume fructose.
Research published in international journals Frontier of endocrinology..
Previous studies have shown that poor quality nutrition during pregnancy can help offspring to have long-term consequences, including the development of obesity, diabetes, and late-life cardiovascular disease.
However, data are lacking to examine the effects of increased fructose intake before and during pregnancy and its subsequent adverse effects on breastfeeding, fetal development, and metabolic function in offspring. “
Erin Smith, First Author, PhD Student
Two groups received a control or fructose diet before and during pregnancy. The fructose group was supplemented with fructose water to increase the intake of sugar-sweetened beverages from 60 days before mating to the birth of offspring. Fructose accounts for 16.5% of the diet, very similar to the average human fructose/sugar consumption in the Western world. This is estimated to be about 14% of the average daily caloric intake.
“Fructose was found to have a significant effect on the metabolic status and free fatty acid content of breast milk in pregnant women. Also, offspring born to fructose-fed mothers had a very specific increase in free fatty acids.” Changes in lipid metabolism that show a unique pattern and continue throughout the early life
Smith is well known that increased levels of circulating free fatty acids increase the risk of obesity, insulin resistance, type 2 diabetes, and cardiovascular disease, which can lead to increased fatty acid synthesis after fructose intake. Is shown.
She suggests that suboptimal mothers’ diets, such as those rich in fructose and refined sugars, may contribute to the increased metabolic disorders in humans observed over the last 40-50 years. She shows evidence.
“Our study emphasizes the importance of limiting additional refined fructose, such as sugar-sweetened beverages, and provides a more nutritionally balanced diet for women before and during pregnancy and lactation. Is working hard.”
Source:
See journal:
LaRae Smith, EV, other (2020) Fructose consumption during pregnancy affects milk lipid composition and progeny lipid profile in guinea pigs. Frontier of endocrinology. doi.org/10.3389/fendo.2020.00550..
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