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Why Coronavirus Pooled Testing Does Not Work

 


Pooling accounts for about one-third of poplar-treated samples, Sweeney added, “the percentage will be much higher.”

But in many other areas, experts struggle to clear the hurdles to benefiting from the pool. This is partly because needs vary widely from institution to institution and even from test to test.

“We had a lot of concerns about all the challenges,” said Dr. Bobiprit, head of the Clinical Parasitology Institute at Mayo Clinic, processing tens of thousands of coronavirus tests each week, but still rolling out the pool. I have not.

For example, experts are divided on cutoffs that make pools useless. The Centers for Disease Control and Prevention coronavirus test Used by most public health laboratories The United States stipulates that the pool should not be used if the positive rate exceeds 10%. But at the Mayo Clinic, “you have to question that if the prevalence goes above 2%, you’ll definitely go above 5%,” Dr. Pritt said.

Prevalence is not the only factor. The more individual samples that are grouped together, the more efficient the process. But at some point, the benefits of pooling reach an inflection point. Positive samples will only be very thin until no coronavirus is detected. So, pooling misses some people who have very small amounts of the virus.

“If we miss them, will we be harmed? I think that’s still a difficult question to answer,” Dr. Leedsman said. These people are less likely to transmit the virus to others and may be at lower risk of becoming seriously ill. But that is not a guarantee. Some are in the early stages of infection.

Pooling can also be a nuisance for lab technicians. Many have spent hours harshly for months. Although theoretically simple, batching samples is tedious and time consuming. Researchers carefully transfer the correct amount of liquid from one tube to another hundreds, perhaps thousands.

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