Health
University of Calgary Research Gains Insight into Skin Regeneration After Severe Burns or Injuries
Calgary-A new study at the University of Calgary has taken the first step towards understanding how to heal skin.
“We have identified specific progenitor cell populations that reside within the deep connective tissue of the dermis, the skin,” said Jeff Biernaskie, Veterinary Medicine (UCVM) and Calgary Firefighters U-C Veterinary Medicine Professor of Stem Cell Biology. Said. Chairman of the burn treatment association in skin regeneration and wound healing.
“Progenitor cells are unique in that they can undergo cell division and generate many new cells to maintain or repair tissue.”
The new study, led by Biernaskie and published in the scientific journal Cell Stem Cell, was co-authored by Dr. Sepideh Abbasi, Dr. Sarthak Sinha and Dr. Elodie Labit.
An intensive five-year study provides new insights into why certain dermal cells can regenerate new skin rather than scar tissue.
According to a news release, genomics technology was used to profile thousands of cells at various time points after injury, after which a team of researchers compared scarring and regenerating areas within skin wounds.
“Surprisingly, we found that although these cells were derived from the same cellular origin, different microenvironments within the wound activate a completely different set of genes,” Biernaskie said. Of the genes normally involved in skin development.
“On the other hand, in the scar formation zone, these regrowth-promoting programs are either absent or suppressed, and the scar formation program predominates.”
These findings allow the team to show that it is possible to modify the genetic methods that control skin regeneration.
“What we have shown is that we can modify the wound environment with drugs and directly modify the genetics of these progenitor cells, both of which are sufficient to alter behavior during wound healing,” Bianasky said. Said.
“And it can have a really very impressive effect on healing, including the regeneration of new follicles, glands, and fat in damaged skin.”
The next step in this study is to develop drugs that prevent scar formation and improve skin healing.
“Proof of this principle is very important because it suggests that adult wound-responsive cells actually have potential regenerative capacity. It just needs to be uncovered. Biernaskie said.
“We are now actively looking for additional pathways that may be involved. Our hope is to completely prevent genetic programs that initiate scar formation in order to significantly improve the quality of skin healing. To develop a cocktail of drugs that can be safely administered to humans and animals.”
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