Health
Why being “morning people” is associated with a high risk of Alzheimer’s disease
Studies show that people at high genetic risk for Alzheimer’s disease are more likely to call themselves “morning people.”
The researchers also found that people who were at increased risk of developing a progressive condition were less likely to have insomnia.
The findings, published in the journal Neurology, are based on an analysis of data collected from various genome-wide association studies, including the identification of genes associated with various human diseases.
Teams including scientists at Imperial College in London said they found no evidence of disturbed sleep patterns that could cause Alzheimer’s disease, but added that those at higher risk were more likely to have shorter sleep hours.
But scientists warned that the impact of these associations would be very small, showing only possible links, not causes and consequences.
The researchers looked at data from the International Genomics of the Alzheimer’s Disease Project, which included 63,926 participants, and information from the Psychiatric Genomics Consortium, which included 18,759 participants.
The study also includes data from about 450,000 UK Biobanks who carry about 500,000 health and genetic information.
Scientists used a method called Mendelian randomization to evaluate the relationship between different sleep patterns, major depressive disorder, and genetic risk of Alzheimer’s disease.
Dr. Abbas Dehghan of Imperial, the author of the study, said:
“I wanted to know if there was a causal relationship between different sleep patterns and depression and Alzheimer’s.”
The researchers said there was no evidence of a causal relationship between major depressive disorder and Alzheimer’s disease.
However, we found that people who had a double genetic risk of Alzheimer’s disease were 1% more likely to call themselves “morning people” than people with a low genetic risk.
They also found that people with twice the genetic risk of Alzheimer’s disease have a 1% lower risk of insomnia.
Researchers said the results may not apply to people of other ethnic backgrounds, because most of the people in the study were of European ancestry.
Dr. Sarai Maricio, head of research at Alzheimer’s Research UK, commented on the study: “Many of us know that sleep at night is bad and can affect memory and thoughts in the short term. An interesting issue is that sleep problems have long-term effects on the brain. Or not.
“This study shows a small link between different sleep patterns and the risk of developing Alzheimer’s disease, but we found no evidence of sleep disorders that cause the disease.”
“Dementia is not an unavoidable part of aging, and more evidence is needed on the complex topic of sleep before determining its impact on dementia risk.”
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