Intraoperative radiation therapy as effective as external beam radiation therapy

Researchers have shown that in the case of early-stage breast cancer, a single dose of targeted intraoperative radiation therapy (TARGIT-IORT) is as effective as standard treatment in preventing breast cancer recurrence.

Long-term survival outcomes of trials testing single-dose risk-adjusted targeted intraoperative radiation therapy (TARGIT-IORT) as a treatment for early-stage breast cancer were between conventional treatment and long-term survival and cancer recurrence between conventional treatments. External beam radiation therapy (EBRT) shows that there is no statistically significant difference.

In the TARGIT-A (TARGIT-IORT Alone) trial, TARGIT-IORT, a radiation therapy that takes only 20 to 30 minutes during surgery and eliminates the need for subsequent hospital visits, is as effective as long-term prevention of breast cancer. I tried to see if. Recurrence as EBRT. Patients receive 3 to 6 weeks of treatment requiring 15 to 30 visits.

TARGIT-IORT is delivered to the site where the tumor was during the lumpectomy surgery. Treatment is via a small ball-shaped device placed in the space where the tumor has been removed.

To establish the long-term efficacy of the treatment, we randomly assigned 2,298 women over the age of 45 years with invasive ductal carcinoma with a tumor size of 3.5 cm to receive either TARGIT-IORT or EBRT. The trial enrolled patients in 32 centers in 10 countries and started in March 2000.

In this study, the researchers found that risk-adapted single-dose TARGIT-IORT during mastectomy was an effective alternative to EBRT for patients with early-stage breast cancer who met the test criteria and was an equivalent alternative to tumor suppression and low-breast cancer. Mortality that showed long-term efficacy of. They also emphasized that 8 in 10 patients receiving treatment do not require postoperative radiation therapy.

“TARGIT-IORT allows women to undergo surgery for breast cancer and radiation at the same time. This will reduce the amount of time they spend in the hospital and allow them to recover faster. You can go back to life,” says lead author Professor Jayant Vaidya, University College London, Surgery and Interventional Sciences, UK.

“With the announcement of these very positive long-term results, it is now clear that this treatment should be made much more freely available. It is accessible to healthcare providers and surgery for breast cancer is planned. Sometimes we need to talk to patients.”

Compared to EBRT, TARGIT had fewer side effects and fewer heart attacks and deaths from other cancers. TARGIT is cheaper than EBRT and can save £9.1 million a year on UK National Health Services (NHS).

This study British Medical Journal..

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