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Covid-19 Pandemic: Decoding gender differences in immune response to coronavirus-Health


Studies that may help guide a sex-based approach to treatment and care for people infected with the novel coronavirus show that women with COVID-19 persist more strongly through body T cells than men do. Shows a positive immune response.

Published in Nature magazine, the study evaluated 98 patients admitted to the Yale New Haven Hospital in the United States for mild to moderate illness and confirmed positive tests for a novel coronavirus infection.

Previous studies have shown that men with COVID-19 tend to be more severe than women, but the underlying reason for this discrepancy is that scientists, including researchers at Yale University in the United States, According to him, it is still unknown. In the current study, they found that female patients mount a stronger and lasting immune response via T cells in the body than do males. Researchers have stated that T cells play an important role in the immune system with their role including killing infected cells. Poor T-cell responses were associated with worse disease outcomes in male patients, according to scientists including Akiko Iwasaki of the Yale University School of Medicine.

“We found that poor T cell responses were negatively correlated with patient age and were associated with worse disease outcomes in male patients but not in female patients,” the researchers say. Are writing in the study.

Compared to healthy controls, COVID-19 patients were found to have elevated levels of innate immune cytokines and chemokines, signaling molecules involved in recruitment of immune cells to sites of inflammation, he said. ..

However, the study noted that levels of some of these molecules were higher in male than in female patients. In female patients, higher levels of cytokine molecules exacerbated the disease response, according to scientists. Based on the results, they said, while male patients may benefit from treatments that enhance T cell responses, female patients may benefit from treatments that diminish early innate immune responses. However, scientists have warned that they could not rule out other underlying factors that may correct the risk of poor outcome in COVID-19 male and female patients.

(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)

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