Health
Antiviral Drugs for Cats May Help Fight Human COVID-19: A Study
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(IANS)
Researchers are preparing to begin clinical trials of a drug to cure COVID-19 in cats. They hope to be effective as a human treatment for the disease.
“In just two months, this drug is effective at inhibiting intracellular viral replication at SARS-CoV-2,” said Joanne Lemieux, a research researcher at the University of Alberta (UA) in Canada. Was shown.”
“Because the drug is likely to be effective in humans, we encourage it to be an effective antiviral treatment for COVID-19 patients,” added Lemieux.
Drugs are protease inhibitors that interfere with the ability of the virus to replicate and end the infection. Natural communication report.
Proteases have been the key to many bodily functions and have been common targets for drugs to treat everything from hypertension to cancer and HIV. Protease Inhibitors, first studied by John Vedras and Michael James of the UA after the Severe Acute Respiratory Syndrome (SARS) in 2003, have shown to cure fatal illness in cats, a veterinary study Further developed by The researchers explained that Bederas synthesized the compounds, and researcher Lone Tyrrell tested them against the SARS-CoV-2 virus in vitro and in human cell lines.
After that, the research team revealed the crystal structure of the drug that binds to the protein. “We determined the three-dimensional shape of the protease by using the drug in the active site pocket, which shows a mechanism of inhibition. This will allow us to develop more effective drugs,” Remu said. ..
Lemieux further said he will continue to test the inhibitor modifications to ensure they fit well within the virus. However, she said the current drugs show sufficient antiviral activity against SARS-CoV-2 and can go into clinical trials immediately.
“Usually, before a drug can go into clinical trials, it needs to be confirmed in the lab and then tested in an animal model,” Remu said.
“This drug has already been used to treat cats with coronaviruses and is effective because it has little or no toxicity, so it has already gone through these stages, which allows it to move forward. She added.
The researchers have established a collaboration with Anivive Life Sciences, a veterinary drug company that develops medicines for cats to produce the quality and quantity of medicines needed for human clinical trials. The team said it would likely be tested in Alberta in combination with other promising antiviral drugs such as lemdesibir.
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