Health

Weight of major risk factors for diabetes over genetics: a study

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(N Kanaka / BCCL, Visakha Putnam)

Losing weight can even prevent or reverse diabetes, the researchers said, the Body Mass Index (BMI) is a stronger risk factor for diabetes than genetics. BMI is a measure of body fat based on height and weight.

Obesity is the major correctable cause of type 2 diabetes. At the same time, genetic makeup may also identify individuals who are more likely to develop the condition, a study presented at the ESC Congress 2020 conference on Monday revealed.

“Being born with a gene, we may be able to identify early in life that diabetes is more likely to develop during life,” says Cambridge University researcher Brian Fence. Said at Cambridge University in the UK.

“We conducted this study to see if combining genetic risk with the current body mass index (BMI) could identify people at highest risk of developing diabetes,” Ferren added.

The survey included 4,45,765 participants from the UK Biobank. The average age was 57.2 and 54% were female.

The genetic risk of diabetes was assessed using 6.9 million genes, according to the researchers. Height and weight were measured at enrollment to calculate BMI. Participants were divided into five groups according to the genetic risk of diabetes. It was also divided into 5 groups according to BMI. In addition, participants were followed up to an average age of 65.2 years. During that period, 31,298 people developed type 2 diabetes.

The results show that participants in the highest BMI group were 11 times more likely to have diabetes than those in the lowest BMI group. The highest BMI group was more likely to develop diabetes than all other BMI groups, regardless of genetic risk.

“The findings show that BMI is a far stronger risk factor for diabetes than a genetic predisposition,” Ference said.

Researchers then used statistical methods to estimate whether people with a high BMI were more likely to have diabetes if they were overweight over a long period of time. They found that the duration of elevated BMI did not affect the risk of diabetes.

“This suggests that when people cross a certain BMI threshold, they are more likely to have diabetes and remain at the same high risk level regardless of overweight,” Ference said. .. He also pointed out that it may be possible to reverse diabetes by losing weight early on before permanent damage occurs.

The Weather Company’s primary journalism mission is to report on the latest weather news, the environment, and the importance of science to our lives. This story does not necessarily represent the position of the parent company, IBM.

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