Health
Patients with COVID-19 need to remain on ACE inhibitor, ARB
Based on the results of the first randomized trial investigating this issue, heart disease patients were angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers when hospitalized for coronavirus disease 2019 (COVID-19). You can continue to take your medicine (ARB) safely.
Data from Brace corona In a study published on Tuesday at the European Heart Association, no difference was found between patients who continued to take ACE inhibitors or ARBs and those who were discontinued for 30 days after being diagnosed with COVID-19. did. The study, led by Dr. Renato Lopez, MD of the Duke Clinical Laboratory in Durham, NC, enrolled 659 patients in 29 locations in Brazil.
Patients were followed for 30 days after diagnosis. The results showed that patients who discontinued medication had an average survival and discharge of 21.9 days and patients who continued had a 22.9 days duration. The average difference in clinical status at day 30 between groups was -1.1 days.
“This is the first randomized data to assess the role of ACE inhibitors and ARBs in continuing and stopping in COVID-19 patients,” says Lopes. “These data indicate that inpatients with mild to moderate COVID-19 have no clinical benefit from regular discontinuation of these drugs, so It usually needs to continue.”
The results confirm initial recommendations from major professional societies that patients should continue to take their medications, he said.
Since the onset of the COVID-19 pandemic, clinicians have been addressing the question of whether patients should continue to receive these medications. There was concern about the association between angiotensin converting enzyme 2 (ACE2) and SARS-CoV-2. ACE2 is considered a gateway for the virus that causes COVID-19 and may make COVID-19 more dangerous in some patients. .. Yet other evidence suggests that renin-angiotensin-aldosterone inhibitors can reduce COVID-19-induced acute lung injury.
The researchers ruled out patients who were on three or more antihypertensive drugs or sucvitril/valsartan or who were hemodynamically unstable at admission.
Lopez also told reporters at a press conference that the trial also had several secondary endpoints, such as myocardial infarction and stroke, and disease progression as measured by whether the patient was intubated or in the intensive care unit. I told you I investigated. “Basically, the results are very consistent,” he said. “And there is no significant difference in treatment strategy at any of the major secondary endpoints evaluated in the trial.”
He also said he will publish the results of the subgroup analysis later, including age group and results for obese patients.
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