Research says toxins form when e-cigarette chemicals mix

Thursday, September 03, 2020 (HealthDay News)-Even worse news about e-cigarettes: Researchers show a previously unknown toxin that could affect the heart and lungs of smokers Was identified.

Studies show that when manufacturers combine e-cigarette flavors and solvents, chemicals are formed. These chemicals can stimulate the respiratory tract and cause reactions that can cause respiratory, heart, and vascular problems.

Sven-Eric Jordt, associate professor of anesthesia, pharmacology, and cancer biology at Duke University, said, “We are concerned about the high levels of these new compounds that have not been studied in the past and want to conduct toxicity studies. I have decided.” Medicine in Durham, North Carolina

The bronchi, the main airway from the trachea to the lungs, “is exposed to e-cigarette vapors when a user inhales into the lungs,” said Joart. “We consistently observed that the new chemicals formed from flavors and e-liquid solvents were more toxic than either of their parent compounds.”

Under public pressure, the US Food and Drug Administration has withdrawn mint, fruit, and dessert-flavored e-cigarette cartridges from the US market since January 2019. The menthol-flavored vape continues to be allowed for sale, with one other important exception. The flavored liquid nicotine used in the “open tank system” was not illegal.

A newly-identified chemical discovered by the group of yotos, born as a combination of fragrance and solvent, appears to activate sensory stimulatory receptors on nerve endings in the bronchi. And it can cause various harmful inflammatory reactions.

“Activation of sensory stimulators can increase heart rate and, in predisposed people, can cause irregular heartbeat and hypertension. Also, secretions in the nasal cavity, lungs, and airways Can cause coughing and dyspnea,” said Jord.

One respiratory expert who reviewed the findings said it would add to the list of reasons to avoid vaping.

“This is the first demonstration of how vaping’s metabolites can be damaged at the cellular level,” said Margarita Oks, a doctor at the Lennox Hill Hospital in New York City. Said. “Usually, chemical reactions produce less toxic and less toxic end products.”

The findings were presented on Thursday at a virtual meeting of the European Respiratory Society.

E-cigarette makers claim that their products are safe because they evaporate known stable chemicals.

But the study found that cells that line the bronchi die, even at low concentrations of chemicals, he said.

“This is the first demonstration that these new chemicals formed in e-liquid can damage and kill lung cells, and perhaps by impairing their metabolism. In some cases, flavor chemicals More than 40% is converted to new chemicals by e-cigarettes, little known so far about its toxicity,” Jord said in a social news release.

“Our findings suggest that e-cigarettes release unstable chemical mixtures containing a wide variety of chemicals with unexpected toxicological properties. Regulators are forming these compounds It is important to note that toxicity studies can be initiated to assess safety.”

Patricia Forlan instructed Northwell Health’s Tobacco Control Center in Great Neck, New York, saying, “It may be necessary to investigate further, but it is clear that e-cigarettes contain known toxic compounds. “As yet undiscovered and unverified.”

“While waiting for these studies, I think it important to warn the public, especially young people, about the harmful effects of the use of e-cigarettes, especially products containing fragrances,” he said.

Joet agreed that regulators should conduct or fund additional research into the fate of chemicals in e-liquids, especially toxicology. Once the toxicity level is known, policymakers can assess the level of risk to users and issue updated recommendations to manufacturers, he said.

The new findings were presented at a medical conference, so data should be considered preliminary until published in a peer-reviewed medical journal.

For more information

The US Department of Health and Human Services Electronic cigarette risk..