Multiple systemic inflammatory syndrome (MIS-C) in children thought to be associated with COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing, Some children damage the heart enough to require lifelong monitoring and intervention, a senior author of a medical review said.
This review was published in The Lancet’s journal, EClinical Medicine.
Case studies have also shown that MIS-C can attack seemingly healthy children without warning 3 or 4 weeks after subclinical infection. Dr. Moreira, a neonatal specialist, is an assistant professor of pediatrics at the University of Joe R. and Theresa Rosano Long School of Medicine.
“According to the literature, children did not have to have the classic upper respiratory symptoms of COVID-19 to develop the dreaded MIS-C,” Dr. Moreira said. “Children may be asymptomatic, not everyone knew they had the disease, and after a few weeks, they might develop this exaggerated inflammation in the body. .”
The team reviewed 662 MIS-C cases reported worldwide from January 1st to July 25th.
Among the findings:-71% of children were admitted to the intensive care unit (ICU). -60% showed shock. -The average length of stay in hospital was 7.9 days. -100% fever, 73.7% fever Abdominal pain or diarrhea, 68.3% vomiting. -90% had echocardiography (EKG) and 54% of the results were abnormal. -22.2% of children needed artificial respiration. -4.4% required extracorporeal membrane oxygenation (ECMO).-11 children died.
“This is a new childhood disease that is thought to be associated with SARS-CoV-2,” Dr. Moreira said. “It can be fatal because it affects multiple organ systems. Whether it’s the heart, lungs, gastrointestinal system, or nervous system, it has so many different aspects that It was difficult for clinicians to understand.”
The amount of MIS-C inflammation exceeds that of two similar children, Kawasaki disease and toxic shock syndrome. “The benefit of the savings was that these patients could be effectively treated with treatments commonly used in Kawasaki-immunoglobulin and glucocorticosteroids,” Dr. Moreira said.
Most of the 662 children suffered a heart attack, as indicated by markers such as troponin.
“Approximately 90% (581) of the children had echocardiography because they had prominent cardiac symptoms of such a disease,” Moreira said.
-Expansion of coronary blood vessels, a phenomenon also seen in Kawasaki disease. -Low ejection rate. Indicates that the heart’s ability to pump oxygenated blood into the tissues of the body is diminished.
Almost 10% of children had coronary aneurysms. “This is a local stretch or bulge of blood vessels that can be measured by ultrasound of the heart,” Dr. Moreira said.
Children with aneurysms are at the highest risk of future events. “These are children who need significant observation and follow-up with multiple ultrasounds to see if this resolves, or if they have it for the rest of their lives,” Dr. Moreira. Said.
“It’s devastating to parents who had previously had healthy children, and then he/she is a small percentage of individuals who developed MIS-C after COVID-19 infection,” he said.
Another finding from a case study: Nearly half of patients with MIS-C had an underlying medical condition, and of them, half of the individuals were obese or overweight.
“In general, obese patients will have worse consequences, both in adults and children,” Dr. Moreira said.
The inflammatory markers of MIS-C were much more abnormal when compared to the original COVID-19 infection. For example, troponin, a marker used to diagnose heart attacks in adults, was 50 times above normal levels in children with MIS-C.
“Evidence suggests that children with MIS-C have significant inflammation and potential tissue damage to their hearts. Must be carefully tracked.”
(This article has been published from the telegraph agency feed with no changes to the text. Only the headings have changed.)
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