Health
A cold, an unlikely ally who fights a cold
As the flu season approaches, the strained public health system may have a surprising ally, the common cold virus.
Rhinovirus, the most frequent cause of colds, can prevent the influenza virus from infecting the respiratory tract by rapidly initiating the body’s antiviral defenses.
The findings will help answer the mystery surrounding the 2009 H1N1 swine flu pandemic. In Europe, the expected surge of swine flu cases did not materialize in the fall season when colds are widespread.
The Yale team, led by Dr. Ellen Foxman, examined three-year clinical data of over 13,000 patients with respiratory infections at Yale New Haven Hospital. Researchers found that even during the months when both viruses were active, the influenza virus was absent if the common cold virus was present.
“The data revealed that very few people were infected with both viruses at the same time,” said Foxman, assistant professor of medicine and immunobiology, and lead author of the study. Said.
Foxman stressed that scientists do not know if the annual seasonal spread of the common cold virus would have a similar effect on the prevalence of people exposed to the COVID-19-causing coronavirus. ..
“It is impossible to predict how two viruses will interact without doing research,” she said.
To test how rhinoviruses and influenza viruses interact, Foxman’s lab covers human airways from stem cells that cover the airways of the lung and give rise to epithelial cells, which are the primary targets of respiratory viruses. I created an organization. They found that the influenza virus was unable to infect the tissue after it was exposed to the rhinovirus.
“By the time the influenza virus arrived, anti-virus protection was already on,” she said.
The presence of rhinovirus caused the production of the antiviral drug interferon, which is part of the early immune system’s response to pathogen invasion, Foxman said.
“The effect lasted for at least 5 days,” she said.
According to Foxman, her lab has begun investigating whether introducing a cold virus before infecting the COVID-19 virus would provide similar protection.
reference
Wu A, Mihaylova VT, Landry ML, Foxman EF. Rhinovirus-Influenza A Virus Interference: Clinical Data Analysis and Experimental Infection Studies. Lancet microorganisms. 2020; 0 (0). doi: 10.1016 / S2666-5247 (20) 30114-2
This article was reissued from material.. Note: Materials may have been edited in length and content. Contact the source for more information.
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